Adipogen/SB415286/AG-CR1-3658-M025/25 mg
商品编号：
AG-CR1-3658-M025
品牌：
Adipogen Inc
市场价：
¥7600.00
美元价：
4560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| ProductType | Chemical |
| Properties | |
| Formula | C16H10ClN3O5 |
| MW | 359.7 |
| CAS | 264218-23-7 |
| PurityChemicals | ≥97% |
| Appearance | Yellowsolid. |
| Solubility | SolubleinDMSO(10mg/ml),ethanol(5mg/ml)ormethanol. |
| InChiKey | PQCXVIPXISBFPN-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentandselectivecellpermeable,ATP-competitiveinhibitorofGSK3αwithanIC50valueof78nM(andsimilarpotencyforGSK3β).
- DYRK1Ainhibitor(IC50=0.9µM).
- Stimulatesglycogensynthesisinlivercellsandinducesβ-catenin-dependentgenetranscription.
- ActsasneuroprotectantandpreventsneuronalcelldeathinducedbyPI3-kinasepathway.
- Anticanceragentwithantiproliferativeactivity.
- Glycogensynthasekinase3(GSK3)isaserine/threonineproteinkinasethatisinhibitedbyanassortmentofextracellularstimulisuchasinsulin,growthfactors,cellspecificationfactorsandcelladhesion.Itsactivityregulatesmanycellfunctionsincludingthecontrolofcelldivision,apoptosisandinflammation.
ProductReferences
- Selectivesmallmoleculeinhibitorsorglycogensynthasekinase-3modulateglycogenmetabolismandgenetranscription:M.P.Coghlan,etal.;Chem.&Biol.7,793(2000)
- Selectivesmall-moleculeinhibitorsofglycogensynthasekinase-3activityprotectprimaryneuronsfromdeath:D.A.E.Cross,etal.;J.NeuRochem.77,94(2001)
- UseoflithiumandSB-415286toexploretheroleofglycogensynthasekinase-3intheregulationofglucosetransportandglycogensynthase:K.MacAulay,etal.;Eur.J.Biochem.270,3829(2003)
- GSK3inhibitors:developmentandtherapeuticpotential:P.Cohen&M.Goedert;Nat.Rev.DrugDiscov.3,479(2004)
- Reductionofexperimentalcolitisintheratbyinhibitorsofglycogensynthasekinase-3beta:B.J.R.Whittle,etal.;Br.J.Pharmacol.147,575(2006)
- Theselectivityofproteinkinaseinhibitors:afurtherupdate:J.Bain,etal.;Biochem.J.408,297(2007)
- Inactivationofglycogensynthasekinase3promotesaxonalgrowthandrecoveryintheCNS:J.Dill,etal.;J.Neurosci.28,8914(2008)
- AmolecularstudyofpathwaysinvolvedintheinhibitionofcellproliferationinneuroblastomaB65cellsbytheGSK-3inhibitorslithiumandSB-415286:J.G.Pizarro,etal.;J.Cell.Mol.Med.13,3906(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
