Adipogen/SB242235/SYN-1076-M010/10 mg
商品编号：
SYN-1076-M010
品牌：
Adipogen Inc
市场价：
¥13060.00
美元价：
7836.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SB-242235 |
| ProductType | Chemical |
| Properties | |
| Formula | C19H20FN5O |
| MW | 353.4 |
| CAS | 193746-75-7 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:p38|KinaseGroup:CMGC|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | PDTYLGXVBIWRIM-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Thep38mitogen-activatedproteinkinase(MAPK)signalingpathwayisactivatedbynumerousinflammatorymediatorsandenvironmentalstresses.SB-242235isapotentandmoderatelyselectivep38MAPkinaseinhibitorthatmaybeaneffectivetherapyforcytokine-mediateddiseasessuchasautoimmuneorinflammatorydiseases.SB-242235exhibitsgoodoralavailabilityinpreclinicalstudiesandhasmicromolarorsubmicomolarinvivoIC(50)values.HoweveritisclearfromstudiesexaminingSB-242235effectsonmetabolism,forinstanceinchondrocytesandhumancartilagethatSB-242235effectscanbepleiotropicbetweenspeciesandthatcaremustbetakenwhenstudyingtheinteractionsofmulti-targetinhibitorssuchasSB-242235.
ProductReferences
- Disease-modifyingactivityofSB242235,aselectiveinhibitorofp38mitogen-activatedproteinkinase,inratadjuvant-inducedarthritis:A.M.Badger,etal.;ArthritisRheum.43,175(2000)
- Pyrimidinylimidazoleinhibitorsofp38:cyclicN-1imidazolesubstituentsenhancep38kinaseinhibitionandoralactivity:J.L.Adams,etal.;Bioorg.Med.Chem.Lett.11,2867(2001)
- SB-242235,aselectiveinhibitorofp38mitogen-activatedproteinkinase.I:preclinicalpharmacokinetics:K.W.Ward,etal.;Xenobiotica32,221(2002)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
