Adipogen/SB216763/AG-CR1-3659-M025/25 mg
商品编号：
AG-CR1-3659-M025
品牌：
Adipogen Inc
市场价：
¥4800.00
美元价：
2880.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| ProductType | Chemical |
| Properties | |
| Formula | C19H12Cl2N2O2 |
| MW | 371.2 |
| CAS | 280744-09-4 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Orangepowder. |
| Solubility | SolubleinDMSO(20mg/ml)orethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | JCSGFHVFHSKIJH-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentandselectivecellpermeable,ATP-competitiveinhibitorofGSK3αwithanIC50valueof34nM(andsimilarpotencyforGSK3β).
- DYRK1Ainhibitor(IC50=0.8µM).
- Stimulatesglycogensynthesisinlivercellsandinducesβ-catenin-dependentgenetranscription.
- ActsasneuroprotectantandpreventsneuronalcelldeathinducedbyPI3-kinasepathway.
- Anticanceragentwithantiproliferativeactivity.
- Reducespulmonaryinflammationandfibrosisinamousemodel.
- Showntodelaypreconditioning,reducesinfarctsizeandpreventscardiacischemia.
- Promotespluripotencyinmouseembryonicstemcells.
- Glycogensynthasekinase3(GSK3)isaserine/threonineproteinkinasethatisinhibitedbyanassortmentofextracellularstimulisuchasinsulin,growthfactors,cellspecificationfactorsandcelladhesion.Itsactivityregulatesmanycellfunctionsincludingthecontrolofcelldivision,apoptosisandinflammation.
ProductReferences
- Selectivesmallmoleculeinhibitorsofglycogensynthasekinase-3modulateglycogenmetabolismandgenetranscription:M.P.Coghlan,etal.;Chem.Biol.7,793(2000)
- Selectivesmall-moleculeinhibitorsofglycogensynthasekinase-3activityprotectprimaryneuronesfromdeath:D.A.Cross,etal.;J.NeuRochem.77,94(2001)
- GSK3inhibitors:developmentandtherapeuticpotential:P.Cohen&M.Goedert;Nat.Rev.DrugDiscov.3,479(2004)
- Theselectivityofproteinkinaseinhibitors:afurtherupdate:J.Bain,etal.;Biochem.J.408,297(2007)
- Regulationandfunctionofglycogensynthasekinase-3isoformsinneuronalsurvival:M.H.Liang&D.M.Chuang;J.Biol.Chem.282,3904(2007)
- Delayedcardioprotectionaffordedbytheglycogensynthasekinase3inhibitorSB-216763occursviaaKATP-andMPTP-dependentmechanismatreperfusion:E.R.Gross,etal.;Am.J.Physiol.HeartCirc.Physiol.294,H1497(2008)
- 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione(SB216763),aglycogensynthasekinase-3inhibitor,displaystherapeuticpropertiesinamousemodelofpulmonaryinflammationandfibrosis:C.Gurrieri,etal.;J.Pharmacol.Exp.Ther.332,785(2010)
- Glycogensynthasekinase3(GSK3)inhibitor,SB-216763,promotespluripotencyinmouseembryonicstemcells:L.A.Kirby,etal.;PLoSOne7,e39329(2012)
- GSK-3inhibitorinhibitscellproliferationandinducesapoptosisinhumanosteosarcomacells:H.Nishimura,etal.;Oncol.Rep.35,2348(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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