脂肪原/SB216763/AG-CR1-3659-M001/1毫克
商品编号：
AG-CR1-3659-M001
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Product Type | Chemical |
| Properties | |
| Formula | C19H12Cl2N2O2 |
| MW | 371.2 |
| CAS | 280744-09-4 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Orange powder. |
| Solubility | Soluble in DMSO (20mg/ml) or ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | JCSGFHVFHSKIJH-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Potent and selective cell permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 34nM (and similar potency for GSK3β).
- DYRK1A inhibitor (IC50=0.8µM).
- Stimulates glycogen synthesis in liver cells and induces β-catenin-dependent gene transcription.
- Acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway.
- Anticancer agent with antiproliferative activity.
- Reduces pulmonary inflammation and fibrosis in a mouse model.
- Shown to delay preconditioning, reduces infarct size and prevents cardiac ischemia.
- Promotes pluripotency in mouse embryonic stem cells.
- Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis and inflammation.
Product References
- Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription: M.P. Coghlan, et al.; Chem. Biol. 7, 793 (2000)
- Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death: D.A. Cross, et al.; J. Neurochem. 77, 94 (2001)
- GSK3 inhibitors: development and therapeutic potential: P. Cohen & M. Goedert; Nat. Rev. Drug Discov. 3, 479 (2004)
- The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007)
- Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival: M.H. Liang & D.M. Chuang; J. Biol. Chem. 282, 3904 (2007)
- Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion: E.R. Gross, et al.; Am. J. Physiol. Heart Circ. Physiol. 294, H1497 (2008)
- 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis: C. Gurrieri, et al.; J. Pharmacol. Exp. Ther. 332, 785 (2010)
- Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells: L.A. Kirby, et al.; PLoS One 7, e39329 (2012)
- GSK-3 inhibitor inhibits cell proliferation and induces apoptosis in human osteosarcoma cells: H. Nishimura, et al.; Oncol. Rep. 35, 2348 (2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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