Adipogen/SB203580/AG-CR1-0030-M005/5 mg
商品编号：
AG-CR1-0030-M005
品牌：
Adipogen Inc
市场价：
¥1400.00
美元价：
840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole |
| ProductType | Chemical |
| Properties | |
| Formula | C21H16FN3OS |
| MW | 377.4 |
| CAS | 152121-47-6 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOormethanol. |
| InChiKey | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,specificp38MAPkinaseinhibitor[1,2,5].
- BindstotheATPbindingsiteofp38MAPkinase[3].
- Tcellproliferationinhibitor[4].
- IL-2productioninhibitor[4].
- SAPK/JNKinhibitor[5].
- COX-1and-2inhibitor[6].
- Raf-1activator[7,8].
- Apoptosisenhancer[9].
- Antiproliferative[10].
- PDK1inhibitor[10].
- Anti-inflammatory[11].
- Review[12].
- Enhancescardiomyogenesisofhumanembryonicstemcells(hESCs)[13].
ProductReferences
- SB203580isaspecificinhibitorofaMAPkinasehomologuewhichisstimulatedbycellularstressesandinterleukin-1:A.Cuenda,etal.;FEBSLett. 364,229(1995)
- Regulationofstress-inducedcytokineproductionbypyridinylimidazoles;inhibitionofCSBPkinase:T.F.Gallagher,etal.;Bioorg.Med.Chem. 5,49(1997)
- Pyridinylimidazoleinhibitorsofp38mitogen-activatedproteinkinasebindintheATPsite:P.R.Young,etal.;J.Biol.Chem. 272,12116(1997)
- Ap38MAPkinaseinhibitorSB203580inhibitsCD28-dependentTcellproliferationandIL-2production:S.G.Ward,etal.;Biochem.Soc.Trans. 25,304S(1997)
- Thep38-MAPKinhibitor,SB203580,inhibitscardiacstress-activatedproteinkinases/c-JunN-terminalkinases(SAPKs/JNKs):A.Clerk&P.H.Sugden;FEBSLett. 426,93(1998)
- Directinhibitionofcyclooxygenase-1and-2bythekinaseinhibitorsSB203580andPD98059.SB203580alsoinhibitsthromboxanesynthase:A.G.Börsch-Haubold,etal.;J.Biol.Chem. 273,28766(1998)
- Raf-1isactivatedbythep38mitogen-activatedproteinkinaseinhibitor,SB203580:A.Kalmes,etal.;FEBSLett. 444,71(1999)
- EffectofSB203580ontheactivityofc-Rafinvitroandinvivo:C.A.Hall-Jackson,etal.;Oncogene 18,2047(1999)
- SB203580,aninhibitorofp38mitogen-activatedproteinkinase,enhancesconstitutiveapoptosisofcytokine-deprivedhumaneosinophils:H.Kankaanranta,etal.;J.Pharmacol.Exp.Ther. 290,621(1999)
- ThepyridinylimidazoleinhibitorSB203580blocksphosphoinositide-dependentproteinkinaseactivity,proteinkinaseBphosphorylation,andretinoblastomahyperphosphorylationininterleukin-2-stimulatedTcellsindependentlyofp38mit:F.V.Lali,etal.;J.Biol.Chem. 275,7395(2000)
- SB203580,ap38mitogen-activatedproteinkinaseinhibitor,suppressesthedevelopmentofendometriosisbydown-regulatingproinflammatorycytokinesandproteolyticfactorsinamousemodel:W.D.Zhou,etal.;Hum.Reprod.25,3110(2010)
- p38MAP-kinasespathwayregulation,functionandroleinhumandiseases:A.Cuenda&S.Rousseau;Biochim.Biophys.Acta1773,1358(2007)
- Distinctregulationofmitogen-activatedproteinkinaseactivitiesiscoupledwithenhancedcardiacdifferentiationofhumanembryonicstemcells:H.Kempf,etal.;StemCellRes.7,198(2011)
- Hypoxia/reoxygenation-inducedHMGB1translocationandreleasepromotesisletproinflammatorycytokineproductionandearlyisletgraftfailurethroughTLRssignaling:Y.Cheng,etal.Biochim.Biophys.Acta1863,354(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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