Adipogen/SB202190/AG-CR1-0028-M025/25 mg
商品编号：
AG-CR1-0028-M025
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | FHPI;4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole |
| ProductType | Chemical |
| Properties | |
| Formula | C20H14FN3O |
| MW | 331.3 |
| CAS | 152121-30-7 |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | Solubleinmethanol,DMSOoracetone;slightlysolubleinethylacetate. |
| Identity | Determinedby1H-NMR. |
| InChiKey | QHKYPYXTTXKZST-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentandcellpermeable p38MAPkinase inhibitor[1,2].
- Apoptosisinducer[3].
- Inhibitsp38αandβ,butnotγandδisoforms[4,5].
- DoesnotinhibitERK2orothermembersoftheMAPkinasefamilyortheirupstreamactivators[6].
- JNKactivator[7].
- Autophagicvacuoleinducer[8]
ProductReferences
- Aproteinkinaseinvolvedintheregulationofinflammatorycytokinebiosynthesis:J.C.Lee,etal.;Nature 372,739(1994)
- SB202190,aselectiveinhibitorofp38mitogen-activatedproteinkinase,isapowerfulregulatorofLPS-inducedmRNAsinmonocytes:C.LManthey,etal.;J.Leukoc.Biol.64,409(1998)
- InductionofapoptosisbySB202190throughinhibitionofp38betamitogen-activatedproteinkinase:S.Nemoto,etal.;J.Biol.Chem.273,16415(1998)
- Characterizationofthestructureandfunctionofanewmitogen-activatedproteinkinase(p38beta):Y.Jiang,etal.;J.Biol.Chem. 271,17920(1996)
- Thestructuralbasisforthespecificityofpyridinylimidazoleinhibitorsofp38MAPkinase:K.P.Wilson,etal.;Chem.Biol.4,423(1997)
- AsingleaminoacidsubstitutionmakesERK2susceptIBLetopyridinylimidazoleinhibitorsofp38MAPkinase:T.Fox,etal.;ProteinSci. 7,2249(1998)
- Activationofc-JunN-terminalkinase(JNK)bywidelyusedspecificp38MAPKinhibitorsSB202190andSB203580:aMLK-3-MKK7-dependentmechanism:H.Muniyappa&K.C.Das;Cell.Signal.20,675(2008)
- SB202190-inducedcelltype-specificvacuoleformationanddefectiveautophagydonotdependonp38MAPkinaseinhibition:MB.Menon,etal.;PLosOne6,e23054(2011)
- ApreliminarystudyontheproinflammatorymechanismsofTreponemapallidumoutermembraneproteinTp92inhumanmacrophagesandHMEC-1cells:X.Luo,etal.;Microb.Pathog.110,176(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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