Adipogen/SAR-131675/SYN-1165-M010/10 mg
商品编号：
SYN-1165-M010
品牌：
Adipogen Inc
市场价：
¥13060.00
美元价：
7836.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SAR131675 |
| ProductType | Chemical |
| Properties | |
| Formula | C18H22N4O4 |
| MW | 358.4 |
| CAS | 1092539-44-0 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol.=""> |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:VEGFR-3|KinaseGroup:RTK|Substrate:Tyrosine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | PFMPOBVAYMTUOX-GOSISDBHSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
SAR131675isapotentandselectiveVEGFR-3inhibitor.ItinhibitedVEGFR-3tyrosinekinaseactivityandVEGFR-3autophosphorylationinHEKcellswithIC(50)valuesof20and45nM,respectively.SAR131675dosedependentlyinhibitedtheproliferationofprimaryhumanlymphaticcells,inducedbytheVEGFR-3ligandsVEGFCandVEGFD,withanIC(50)ofabout20nM.SAR131675wasfoundtobehighlyselectiveforVEGFR-3versus107receptors,enzymes,ionchannels,and65kinases.However,itwasmoderatelyactiveonVEGFR-2withaVEGFR-3/VEGFR-2ratioofabout10.SAR131675hadnoantiproliferativeactivityonapanelof30tumorsandprimarycells,furthershowingitshighspecificityandindicatingthatSAR131675isnotacytotoxicorcytostaticagent.
ProductReferences
- SAR131675,apotentandselectiveVEGFR-3-TKinhibitorwithantilymphangiogenic,antitumoral,andantimetastaticactivities:A.Alam,etal.;Mol.CancerTher.11,1637(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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