Adipogen/Salsalate/AG-CR1-3574-G001/1 g
商品编号：
AG-CR1-3574-G001
品牌：
Adipogen Inc
市场价：
¥500.00
美元价：
300.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Salicylsalicylicacid;NSC49171;BRN2590908;2-Hydroxy-2-carboxyphenylester-benzoicacid |
| ProductType | Chemical |
| Properties | |
| Formula | C14H10O5 |
| MW | 258.2 |
| MerckIndex | 14:8339 |
| CAS | 552-94-3 |
| RTECS | DH2080000 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO,ethanolordimethylformamide.Sparinglysolubleinwater. |
| InChiKey | WVYADZUPLLSGPU-UHFFFAOYAY |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Nonacetylatedsalicylate.
- Non-steroidalanti-inflammatorydrug(NSAID).
- Reducespainandinflammationcausedbyconditionssuchasrheumatoidarthritis,osteoarthritisandrelatedrheumaticconditions.
- Prostaglandinsynthesisinhibitorinvivo.
- Inactivatescyclooxygenase-1(COX-1)and-2(COX-2).
- IKKβ/NF-κBinhibitor(atsignificantlyhigherconcentrationsthanrequiredforCOXinhibition).
- Usedtotargetinflammationinthetreatmentofinsulinresistance,type2diabetes,orrheumaticpain.
- Itreducesbloodglucoseconcentrationsinpatientswithtype2diabetes,aswellasininsulin-resistantpatientswithoutdiabetes.
- Reducesbloodglucose,triglyceride,freefattyacidandC-reactiveproteinconcentrations,improvesglucoseutilizationandincreasescirculatinginsulinandADIponectinconcentrationsinobeseadultsatriskforthedevelopmentoftype2diabetesaswellasforpatientswithtype2diabetes.
- Dimericprodrugcomprisingtwoesterifiedsalicylatemoieties.ItisadvantageousoversodiumsalicylatebecauseitisinsolubleattheacidpHofthestomachandpassessUSPendedbutundissolvedintothesmallintestine,sparingthegastricmucosadirectcontact.
ProductReferences
- ReducedriskofNSAIDgastropathy(GImucosaltoxicity)withnonacetylatedsalicylate(salsalate):anendoscopicstudy:S.Roth,etal.; Semin.Arth.Rheum. 19,11(1990)
- InhibitionofNF-kappaBbysodiumsalicylateandaspirin:E.Kopp&S.Ghosh;Science265,956(1994)
- SalicylatesinhibitIkappaB-alphaphosphorylation,endothelial-leukocyteadhesionmoleculeexpression,andneutrophiltransmigration:J.W.Pierce,etal.; J.Immunol. 156,3961(1996)
- Theanti-inflammatoryagentsaspirinandsalicylateinhibittheactivityofI(kappa)Bkinase-beta:M.J.Yin,etal.;Nature396,77(1998)
- Salsalateimprovesglycemiaandinflammatoryparametersinobeseyoungadults:A.Fleischman,etal.;DiabetesCare31,289(2008)
- Useofsalsalatetotargetinflammationinthetreatmentofinsulinresistanceandtype2diabetes:A.B.Goldfine,etal.;Clin.Transl.Sci.1,36(2008)
- Theeffectofsalsalateoninsulinactionandglucosetoleranceinobesenon-diabeticpatients:resultsofarandomiseddouble-blindplacebo-controlledstudy:J.Koska,etal.;Diabetologia52,385(2009)
- Nuclearfactor-kappaBactivationcontributestovascularendothelialdysfunctionviaoxidativestressinoverweight/obesemiddle-agedandolderhumans:G.L.Pierce,etal.;Circulation119,1284(2009)
- Theeffectsofsalsalateonglycemiccontrolinpatientswithtype2diabetes:Arandomizedtrial:A.B.Goldfine,etal.;Ann.Intern.Med.152,346(2010)
- Potentialroleofsalicylatesintype2diabetes:M.M.Rumore&K.S.Kim;Ann.Pharmacother.44,1207(2010)(Review)
- EffectsofsalsalatetherapyonrecoveryfromvascularinjuryinfemaleZuckerfattyrats:S.N.Murthy,etal.;Diabetes59,3240(2010)
- Stimulationofhumanwhole-bodyenergyexpenditurebysalsalateisfueledbyhigherlipidoxidationunderfastingconditionsandbyhigheroxidativeglucosedisposalunderinsulin-stimulatedconditions:R.C.Meex,etal.;J.Clin.Endocrinol.Metab.96,1415(2011)
- Salsalateattenuatesfreefattyacid-inducedmicrovascularandmetabolicinsulinresistanceinhumans:W.Chai,etal.;DiabetesCare34,1634(2011)
- ModelingdiabetesdiseaseprogressionandsalsalateinterventioninGoto-Kakizakirats:Y. Cao,etal.;J.Pharmacol.Exp.Ther.339,896(2011)
- Salsalateimprovesglycemiccontrolinpatientswithnewlydiagnosedtype2diabetes:E.Faghihimani,etal.;ActaDiabetol.50,537(2013)
- Salicylatedownregulates11β-HSD1expressioninadiposetissueinobesemiceandinhumans,mediatinginsulinsensitization:M.Nixon,etal.;Diabetes61,790(2012)
- TheancientdrugsalicylatedirectlyactivatesAMP-activatedproteinkinase:S.A.Hawley,etal.;Science336,918(2012)
- Reductionofinsulinresistanceandplasmaglucoselevelbysalsalatetreatmentinpersonswithprediabetes:E.Faghihimani,etal.;Endocr.Pract.18,826(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
