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Adipogen/SAG . dihydrochloride (water soluble)/AG-CR1-3585-M001/1 mg
Adipogen/SAG . dihydrochloride (water soluble)/AG-CR1-3585-M001/1 mg
商品编号：
AG-CR1-3585-M001
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(4-pyridinyl)benzyl]-1-benzothiophene-2-carboxamide.2HCl |
| ProductType | Chemical |
| Properties | |
| Formula | C28H28ClN3OS.2HCl.3H2O |
| MW | 490.1.72.9.54.0 |
| CAS | 912545-86-9and364590-63-6(bothfreebase) |
| PurityChemicals | ≥98%(HPLC). |
| Appearance | Lightyellowsolid. |
| Solubility | SolubleinwaterorDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | IYXUQUYRWPGIQL-KOONDFAVSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- CellpermeableSonichedgehog(Shh)agoNIST.
- Cellpermeablesmoothened(Smo)agonist.
- InducesSonichedgehog(Shh)pathwayactivationandcounteractscyclopamineinhibitionofSmo.
- ActsasanactivatorofSmoatlowconcentrationsandasaninhibitorofSmoatveryhighconcentrations.
- PotentactivatorofVEGFexpressioninvitro.
ProductReferences
- Small-moleculemodulatorsofHedgehogsignaling:identificationandcharacterizationofSmoothenedagonistsandantagonists:M.Frank-Kamenetsky,etal.;J.Biol.1,10(2002)
- SmallmoleculemodulationofSmoothenedactivity:J.K.Chen,etal.;PNAS99,14071(2002)
- Activity-dependentinternalizationofsmoothenedmediatedbybeta-arrestin2andGRK2:W.Chen,etal.;Science306,2257(2004)
- SmoothenedSignalTransductionisPromotedbyG-ProteinCoupledReceptorKinase2:A.R.Melonietal.;Mol.CellBiol.26,7550(2006)
- OxysterolsstimulateSonichedgehogsignaltransductionandproliferationofmedulloblastomacells:R.B.Corcoran&M.P.Scott;PNAS103,8408(2006)
- IdentificationandcharacterizationofHedgehogmodulatorpropertiesafterfunctionalcouplingofSmoothenedtoG15:C.Masdeu,etal.;BBRC349,471(2006)
- WntsignalingstimulatestranscriptionaloutcomeoftheHedgehogpathwaybystabilizingGLI1mRNA:F.K.Noubissi,etal.;CancerRes.69,8572(2009)
- Evidenceforallostericinteractionsofantagonistbindingtothesmoothenedreceptor:C.M.Rominger,etal.;J.Pharmacol.Exp.Ther.329,995(2009)
- Converseconformationalcontrolofsmoothenedactivitybystructurallyrelatedsmallmolecules:H.Yang,etal.;J.Biol.Chem.284,20876(2009)
- IdentificationofasuppressivemechanismforHedgehogsignalingthroughanovelinteractionofGliwith14-3-3:Y.Asoaka,etal.;J.Biol.Chem.285,4185(2010)
- Smoothenedagonistaugmentsproliferationandsurvivalofneuralcells:O.Bragina,etal.;Neurosci.Lett.482,81(2010)
- Subregionalspecificationofembryonicstemcell-derivedventraltelencephalictissuesbytimedandcombinatorytreatmentwithextrinsicsignals:T.Danjo,etal.;J.Neurosci.31,1919(2011)
- PotentsmallmoleculeHedgehogagonistsinduceVEGFexpressioninvitro:K.Seifert,etal.;Bioorg.Med.Chem.20,6465(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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