Adipogen/S49076 . HCl/SYN-1217-M050/50 mg
商品编号：
SYN-1217-M050
品牌：
Adipogen Inc
市场价：
¥16200.00
美元价：
9720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | S-49076 . HCl; (Z)-3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione hydrochloride |
| Product Type | Chemical |
| Properties | |
| Formula | C22H23ClN4O4S |
| MW | 475.0 |
| CAS | 1265965-19-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: MET, AXL, FGFR | Kinase Group: TK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | FPSAJUOIYZSJJA-NAIZSXBXSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block MET-driven migration of lung carcinoma cells, and inhibit colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. S49076 has also been shown to cause tumour growth arrest in bevacizumab-resistant tumours in xenograft models.
Product References
- S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab: M.F. Burbridge, et al.; Mol. Cancer Ther. 12, 1749 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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