![Adipogen/RF-22c [5-Lipoxygenase Inhibitor]/AG-CR1-3653-M002/2 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-rf-22c.png)
Adipogen/RF-22c [5-Lipoxygenase Inhibitor]/AG-CR1-3653-M002/2 mg
商品编号：
AG-CR1-3653-M002
品牌：
Adipogen Inc
市场价：
¥2200.00
美元价：
1320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3-Dodecyl-4,5-dimethoxy-3,5-cyclohexADIene-1,2-dione;5-LOInhibitorRF-22c |
| ProductType | Chemical |
| Properties | |
| Formula | C20H32O4 |
| MW | 336.5 |
| CAS | 1680206-61-4 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Orangesolid. |
| Solubility | SolubleinDMSO(1mg/ml),ethanolorchloroform.Insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| OtherProductData | Stocksolutions(1mg/ml)arestableupto1monthwhenstoredat-20°C. |
| InChiKey | ROJYDZSFBXLWIR-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SelectiveandreversIBLepotentinhibitorofhuman5-lipoxygenase(5-LO).Thisenzymecatalyzestwoinitialstepsintheconversionofarachidonicacidintoleukotrienes,wellknownmediatorsofinflammatoryandallergicreactions.
- Potentlyinhibits5-LOproductsynthesisintacthumanleukocytes,suchasneutrophilsandmonocytes(IC50≥22nM)andincell-freeassays(IC50≥140nM)withoutaffecting12/15-LOs,cyclooxygenase(COX)-1/2orarachidonicacidrelease.
- Anti-inflammatorycompound.Showspronouncedeffectivenessindifferentmodelsofinflammationinvivoat0.1mg/kg;i.p.Impaired(I)bronchoconstrictioninovalbumin-sensitizedmicechallengedwithacetylcholine,(II)exudateformationincarrageenan-inducedpawedemaand(III)zymosan-inducedleukocyteinfiltrationinairpouches.
ProductReferences
- Novelseriesofbenzoquinoneswithhighpotencyagainst5-lipoxygenaseinhumanpolymorphonuclearleukocytes:R.Filosa,etal.;Eur.J.Med.Chem.94,132(2015)
- The5-lipoxygenaseinhibitorRF-22cpotentlysuppressesleukotrienebiosynthesisincelluloandblocksbronchoconstrictionandinflammationinvivo:A.M.Schaible,etal.;Biochem.Pharmacol.112,60(2016)
- Optimizationofbenzoquinoneandhydroquinonederivativesaspotentinhibitorsofhuman5-lipoxygenase:A.Peduto,etal.;Eur.J.Med.Chem.127,715(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
