Adipogen/Rebeccamycin/BVT-0139-M001/1 mg
商品编号：
BVT-0139-M001
品牌：
Adipogen Inc
市场价：
¥6300.00
美元价：
3780.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC359079;BRN4732638 |
| ProductType | Chemical |
| Properties | |
| Formula | C27H21Cl2N3O7 |
| MW | 570.4 |
| CAS | 93908-02-2 |
| Source/HostChemicals | IsolatedfromStreptomycessp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Yellowsolid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | QEHOIJJIZXRMAN-UMHCKEELSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. Afterreconstitution,preparealiquotsandstoreat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- WeaktopoisomeraseI(TopoI)inhibitor.
- Structurallysimilartostaurosporine.
- Doesnotshowanyinhibitoryactivityagainstproteinkinases.
- Showssignificantantitumorpropertiesinvitro(IC50=480nMagainstmouseB16melanomacellsandIC50=500nMagainstP388leukemiacells).
ProductReferences
- ProductionandBIOLOGicalactivityofrebeccamycin,anovelantitumoragent:J.A.Bush,etal.;J.Antibiot.(Tokyo)40,668(1987)
- DNAcleavagebytopoisomeraseIinthepresenceofindolocarbazolederivativesofrebeccamycin:C.Bailly,etal.;Biochemistry36,3917(1997)
- Synthesesandbiologicalactivities(topoisomeraseinhibitionandantitumorandantimicrobialproperties)ofrebeccamycinanaloguesbearingmodifiedsugarmoietiesandsubstitutedontheimidenitrogenwithamethylgroup:F.Anizon,etal.;J.Med.Chem.40,3456(1997)
- Caloriesfromcarbohydrates:energeticcontributionofthecarbohydratemoietyofrebeccamycintoDNAbindingandtheeffectofitsorientationontopoisomeraseIinhibition:C.Bailly,etal.;Chem.Biol.6,277(1999)
- RebeccamycinderivativesasdualDNA-damagingagentsandpotentcheckpointkinase1inhibitor:C.Marminon,etal.;MolPharmacol74,1620-1629(2008)
- PhaseIIandpharmacokinetictrialofrebeccamycinanaloginadvancedbiliarycancers:A.Dowlati,etal.;CancerChemotherPharmacol65,73-78(2009)
- Newprogressofresearchesincarbazolecompounds:F.Zhang,etal.;ChineseJ.Org.Chem.30,783(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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