Adipogen/Rasfonin/AG-CN2-0173-C500/500 µg
商品编号：
AG-CN2-0173-C500
品牌：
Adipogen Inc
市场价：
¥3600.00
美元价：
2160.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (-)-Rasfonin;TT-1 |
| ProductType | Chemical |
| Properties | |
| Formula | C25H38O6 |
| MW | 434.6 |
| CAS | 303156-68-5 |
| Source/HostChemicals | IsolatedfromTrichurussp. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Tantobrownviscousliquid(oily). |
| Solubility | Solubleinethanol,methanolorDMSO(all1mg/ml). |
| InChiKey | OHRGHFXATDKGOV-MDKHPKFKSA-N |
| Smiles | O=C1O[C@@]([C@H](C[C@@H](C)C/C(C)=C/C)C)([H])C(OC(/C=C/C(C)=C/[C@@H](CO)CCO)=O)C=C1 |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Selectiveapoptosisinducerinras-dependentcells.
- Autophagy(Akt-dependent),apoptosisandnecroptosisinducerinrenalcancercelllines.
- Inducesdeathofras-mutatedpancreatictumor(Panc-1)cellsinvitroandinvivo.
- RobustinhibitorofpancreaticcancerswiththeK-rasmutation.ReducedSos1expressionanddepressedRas-MAPKactivity.
ProductReferences
- Rasfonin,aNewApoptosisInducerinras-dependentCellsfromTalaromycessp.:T.Tomikawa,etal.;J.Antibiot.53,848(2000)
- TotalsynthesisofTT-1(rasfonin),anα-pyrone-containingnaturalproductfromafungusTrichurusterrophilus:K.Akiyama,etal.;Tetrahedron 61,1827(2005)
- TowardtheDevelopmentofaGeneralChiralAuxiliary.EnantioselectiveAlkylationandaNewCatalyticAsymmetricAdditionofSilyloxyfurans:ApplicationtoaTotalSynthesisof(-)-Rasfonin:R.K.Boeckman,etal.;JACS128,11032(2006)
- Rasfonin,anovel2-pyronederivative,inducesras-mutatedPanc-1pancreatictumorcelldeathinnudemice:Z.Xiao,etal.;CellDeathDis.22,e1241(2014)
- Aktinhibitionattenuatesrasfonin-inducedautophagyandapoptosisthroughtheglycolyticpathwayinrenalcancercells:Q.Lu,etal.;CellDeathDis.6,e2005(2015)
- Rasfoninpromotesautophagyandapoptosisviaupregulationofreactiveoxygenspecies(ROS)/JNKpathway:W.Wang,etal.;Mycology7,64(2016)
- Fungalsecondarymetabolitesrasfonininducesautophagy,apoptosisandnecroptosisinrenalcancercellline:H.Sun,etal.;Mycology7,81(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
