Adipogen/Rapamycin/AG-CN2-0025-M001/1 mg
商品编号：
AG-CN2-0025-M001
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Sirolimus;Rapamune;NSC226080;AntibioticAY-22989;WY-090217;RAPA;SILA9268A;CCRIS9024 |
| ProductType | Chemical |
| Properties | |
| Formula | C51H79NO13 |
| MW | 914.2 |
| MerckIndex | 14:8114 |
| CAS | 53123-88-9 |
| RTECS | VE6250000 |
| Source/HostChemicals | IsolatedfromStreptomyceshygroscopicus. |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,methanolorchloroform. |
| InChiKey | QFJCIRLUMZQUOT-KIHCOMIKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- Antibacterialandantifungalproperties[1,2].
- FormsacomplexwithFKBP12andinhibitsthemammaliantargetofrapamycin(mTOR).Inhibitstheresponsetointerleukin-2(IL-2),andtherebyblocksactivationofTandBcells[3,5,6,11].
- Potentimmunosuppressant[4,10]usedasanalternativetocalcineurininhibitors[12].
- Restrictstheproliferationofsmooth-musclecellsbyblockingcellcycleprogressionattheG1/Stransition[7,13].
- Anti-proliferative.Antitumorcompound[14,15].
- Apoptosisenhancer.Activatorofautophagybothinvitroandinvivo[8,9].
- Anti-HIVandanti-agingcompound[16,17].
- Neuroprotective[18].
- Suppressorforself-renewalandvasculardifferentiationpotentialinhemangiomastemcells[19].
- mTORC1inhibitor[20].
ProductReferences
- Rapamycin(AY-22,989),anewantifungalantibiotic.I.Taxonomyoftheproducingstreptomyceteandisolationoftheactiveprinciple:C.Vezina,etal.;J.Antibiot.(Tokyo)28,721(1975)
- Rapamycin(AY-22,989),anewantifungalantibiotic.II.Fermentation,isolationandcharacterization:S.N.Sehgal,etal.;J.Antibiot.(Tokyo)28,727(1975)
- InhibitionofTandBlymphocyteproliferationbyrapamycin:J.E.Kay,etal.;Immunology72,544(1991)
- FK506andrapamycin:novelpharmacologicalprobesoftheimmuneresponse:J.Y.Chang,etal.;TIPS 12,218(1991)(Review)
- Rapamycin-FKBPspecificallyblocksgrowth-dependentactivationofandsignalingbythe70kdS6proteinkinases:J.Chung,etal.;Cell69,1227(1992),
- Rapamycininhibitionofinterleukin-2-dependentp33cdk2andp34cdc2kinaseactivationinTlymphocytes:W.G.Morice,etal.;J.Biol.Chem.268,22737(1993)
- AmammalianproteintargetedbyG1-arrestingrapamycin-receptorcomplex:E.J.Brown,etal.;Nature369,756(1994)
- Rapamycin,apotentimmunosuppressivedrug,causesprogrammedcelldeathinBlymphomacells:S.Muthukkumar,etal.;Transplantation60,264(1995)
- Rapamycinenhancesapoptosisandincreasessensitivitytocisplatininvitro:Y.Shi,etal.;CancerRes.55,1982(1995)
- Mechanismofactionoftheimmunosuppressantrapamycin:F.J.Dumont&Q.Su;LifeSci.58,373(1996)(Review)
- RapamycincausespoorlyreversIBLeinhibitionofmTORandinducesp53-independentapoptosisinhumanrhaBDomyosarcomacells:H.Hosoi,etal.;CancerRes.59,886(1999)
- Rapamycinintransplantation:areviewoftheevidence:R.N.Saunders,etal.;KidneyInt.59,3(2001)(Review)
- Rapamycinincardiovascularmedicine:P.N.Ruygrok,etal.;Intern.Med.J.33,103(2003)(Review)
- Rapamycin:ananti-cancerimmunosuppressant?:B.K.Law;Crit.Rev.Oncol.Hematol.56,47(2005)(Review)
- Tubersandtumors:rapamycintherapyforbenignandmalignanttumors:D.R.Plas&G.Thomas;Curr.Opin.CellBiol.21,230(2009)(Review)
- PotentialuseofrapamycininHIVinfection:M.Donia,etal.;Br.J.Clin.Pharmacol.70,784(2010)(Review)
- Resveratrolandrapamycin:aretheyanti-agingdrugs?M.Kaeberlein;Bioessays32,96(2010)
- Fightingneurodegenerationwithrapamycin:mechaNISTicinsights:J.Bové,etal.;Nat.Rev.Neurosci.12,437(2011)(Review)
- Rapamycinsuppressesself-renewalandvasculogenicpotentialofstemcellsisolatedfrominfantilehemangioma: S.Greenberger,etal.;J.Invest.Dermatol.131,2467(2011)
- InhibitionofthePI3K–AktandmTORC1signalingpathwayspromotestheelongationofvascularendothelialcells:K.Tsuji-Tamura&M.Ogawa;J.CellSci.129,1165(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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