Adipogen/Radicicol/AG-CN2-0021-M005/5 mg
商品编号：
AG-CN2-0021-M005
品牌：
Adipogen Inc
市场价：
¥4800.00
美元价：
2880.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Monorden; NSC 294404; RHI-12648 |
| Product Type | Chemical |
| Properties | |
| Formula | C18H17ClO6 |
| MW | 364.8 |
| Merck Index | 14: 6253 |
| CAS | 12772-57-5 |
| RTECS | RR1105000 |
| Source/Host Chemicals | Isolated from Gilmaniella sp. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to slightly yellow solid. |
| Solubility | Soluble in DMSO, methanol, acetone, ethyl acetate or chloroform. |
| InChi Key | WYZWZEOGROVVHK-HAJNAQHISA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antibiotic [1].
- Protein tyrosine kinase inhibitor [1].
- Has antifungal [4], antimalarial [6], antiangiogenic (in vivo) [2], anti-inflammatory [5] and antiviral activity.
- Cyclooxygenase-2 (COX-2) expression inhibitor without affecting COX-1 expression in LPS-stimulated macrophages [3, 5].
- Induces the differentiation of HL-60 cells into macrophages [4].
- Potent HSP90 inhibitor [7, 9, 12].
- Anticancer compound [7, 9, 12].
- In vivo Rad/Raf interaction inhibitor [8].
- Inhibitor of AP-1-, NF-κB- and serum response factor (SRF)-mediated transcription. Suppresses expression of iNOS (NOS II) [10].
- Non-competitive inhibitor of ATP citrate lyase [11].
- DNA topoisomerase VI and type II DNA topoisomerase inhibitor [13].
- Protects against LPS/IFN-γ-induced neuronal cell death [14].
- Apoptosis inducer [15].
Product References
- Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol: H.J. Kwon, et al.; Cancer Res. 52, 6926 (1992)
- Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis: T. Oikawa, et al.; Eur. J. Pharmacol. 241, 221 (1993)
- Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis: P. Chanmugam, et al.; J. Biol. Chem. 270, 5418 (1995)
- Induction of differentiation of HL-60 cells by the anti-fungal antibiotic, radicicol: Y. Shimada, et al.; J. Antibiot. 48, 824 (1995)
- Inhibitor of protein tyrosine kinase, radicicol, suppresses the expression of cyclooxygenase and pro-inflammatory cytokines in LPS-stimulated rat alveolar macrophage in part by accelerating degradation of mRNA: L. Feng, et al.; Adv. Exp. Med. Biol. 407, 281 (1997)
- Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites: Y. Tanaka, et al.; J. Antibiot. 51, 153 (1998)
- Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol: S.V. Sharma, et al.; Oncogene 16, 2369 (1998)
- Identification of radicicol as an inhibitor of in vivo Ras/Raf interaction with the yeast two-hybrid screening system: S.W. Ki, et al.; J. Antibiot. 51, 936 (1998)
- Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin: S.M. Roe, et al.; J. Med. Chem. 42, 260 (1999)
- Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages: Y.J. Jeon, et al.; J. Pharmacol. Exp. Ther. 294, 548 (2000)
- Radicicol binds and inhibits mammalian ATP citrate lyase: S.W. Ki, et al.; J. Biol. Chem. 275, 39231 (2000)
- Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor: K. Harashima, et al.; Int. J. Radiat. Biol. 81, 63 (2005)
- The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase: D. Gadelle, et al.; Biochem. Pharmacol. 72, 1207 (2006)
- Protective effect of radicicol against LPS/IFN-gamma-induced neuronal cell death in rat cortical neuron-glia cultures: M.J. Sohn, et al.; Life Sci. 80, 1706 (2007)
- Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins: Y.J. Kim, et al.; Mol. Cell Biochem. 359, 33 (2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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