Adipogen/Radicicol/AG-CN2-0021-M001/1 mg
商品编号：
AG-CN2-0021-M001
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Monorden;NSC294404;RHI-12648 |
| ProductType | Chemical |
| Properties | |
| Formula | C18H17ClO6 |
| MW | 364.8 |
| MerckIndex | 14:6253 |
| CAS | 12772-57-5 |
| RTECS | RR1105000 |
| Source/HostChemicals | IsolatedfromGilmaniellasp. |
| PurityChemicals | ≥99%(HPLC) |
| Appearance | Whitetoslightlyyellowsolid. |
| Solubility | SolubleinDMSO,methanol,acetone,ethylacetateorchloroform. |
| InChiKey | WYZWZEOGROVVHK-HAJNAQHISA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- Proteintyrosinekinaseinhibitor[1].
- Hasantifungal[4],antimalarial[6],antiangiogenic(invivo)[2],anti-inflammatory[5]andantiviralactivity.
- Cyclooxygenase-2(COX-2)expressioninhibitorwithoutaffectingCOX-1expressioninLPS-stimulatedmacrophages[3,5].
- InducesthedifferentiationofHL-60cellsintomacrophages[4].
- PotentHSP90inhibitor [7,9,12].
- Anticancercompound[7,9,12].
- InvivoRad/Rafinteractioninhibitor[8].
- InhibitorofAP-1-,NF-κB-andserumresponsefactor(SRF)-mediatedtranscription.SuppressesexpressionofiNOS(NOSII)[10].
- Non-competitiveinhibitorofATPcitratelyase[11].
- DNAtopoisomeraseVIandtypeIIDNAtopoisomeraseinhibitor[13].
- ProtectsagainstLPS/IFN-γ-inducedneuronalcelldeath[14].
- Apoptosisinducer[15].
ProductReferences
- Potentandspecificinhibitionofp60v-srcproteinkinasebothinvivoandinvitrobyrADIcicol:H.J.Kwon,etal.;CancerRes.52,6926(1992)
- Radicicol,amicrobialcelldifferentiationmodulator,inhibitsinvivoangiogenesis:T.Oikawa,etal.;Eur.J.Pharmacol.241,221(1993)
- Radicicol,aproteintyrosinekinaseinhibitor,suppressestheexpressionofmitogen-inducIBLecyclooxygenaseinmacrophagesstimulatedwithlipopolysaccharideandinexperimentalglomerulonephritis:P.Chanmugam,etal.;J.Biol.Chem.270,5418(1995)
- InductionofdifferentiationofHL-60cellsbytheanti-fungalantibiotic,radicicol:Y.Shimada,etal.;J.Antibiot.48,824(1995)
- Inhibitorofproteintyrosinekinase,radicicol,suppressestheexpressionofcyclooxygenaseandpro-inflammatorycytokinesinLPS-stimulatedratalveolarmacrophageinpartbyacceleratingdegradationofmRNA:L.Feng,etal.;Adv.Exp.Med.Biol.407,281(1997)
- Antimalarialactivityofradicicol,heptelidicacidandotherfungalmetabolites:Y.Tanaka,etal.;J.Antibiot.51,153(1998)
- Targetingoftheproteinchaperone,HSP90,bythetransformationsuppressingagent,radicicol:S.V.Sharma,etal.;Oncogene16,2369(1998)
- IdentificationofradicicolasaninhibitorofinvivoRas/Rafinteractionwiththeyeasttwo-hybridscreeningsystem:S.W.Ki,etal.;J.Antibiot.51,936(1998)
- StructuralbasisforinhibitionoftheHsp90molecularchaperonebytheantitumorantibioticsradicicolandgeldanamycin:S.M.Roe,etal.;J.Med.Chem.42,260(1999)
- Radicicolsuppressesexpressionofinduciblenitric-oxidesynthasebyblockingp38kinaseandnuclearfactor-kappaB/Relinlipopolysaccharide-stimulatedmacrophages:Y.J.Jeon,etal.;J.Pharmacol.Exp.Ther.294,548(2000)
- RadicicolbindsandinhibitsmammalianATPcitratelyase:S.W.Ki,etal.;J.Biol.Chem.275,39231(2000)
- Heatshockprotein90(Hsp90)chaperonecomplexinhibitor,radicicol,potentiatedradiation-inducedcellkillinginahormone-sensitiveprostatecancercelllinethroughdegradationoftheandrogenreceptor:K.Harashima,etal.;Int.J.Radiat.Biol.81,63(2005)
- TheHSP90andDNAtopoisomeraseVIinhibitorradicicolalsoinhibitshumantypeIIDNAtopoisomerase:D.Gadelle,etal.;Biochem.Pharmacol.72,1207(2006)
- ProtectiveeffectofradicicolagainstLPS/IFN-gamma-inducedneuronalcelldeathinratcorticalneuron-gliacultures:M.J.Sohn,etal.;LifeSci.80,1706(2007)
- Radicicol,aninhibitorofHsp90,enhancesTRAIL-inducedapoptosisinhumanepithelialovariancarcinomacellsbypromotingactivationofapoptosis-relatedproteins:Y.J.Kim,etal.;Mol.CellBiochem. 359,33(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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