Adipogen/R-848/AG-CR1-3582-M025/25 mg
商品编号：
AG-CR1-3582-M025
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Resiquimod;S28463;R848 |
| ProductType | Chemical |
| Properties | |
| Formula | C17H22N4O2 |
| MW | 314.4 |
| CAS | 144875-48-9 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO,dichloromethaneormethanol.Slightlysolubleinacetonitrileorethylacetate. |
| InChiKey | BXNMTOQRYBFHNZ-DZQCGVKKCS |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Immuneresponsemodifier.Potentantitumorandantiviralcompound[1,3,10,11,13,-16].
- Stimulatesantibodysecretionandcytokineproduction[2].
- Usedasadjuvanttoincreasetheeffectivenessofvaccines[2,7,9,10].
- PotentandselectivesyntheticligandforToll-likereceptor7(TLR7)inmouseandforTLR7andTLR8inhuman[4-6].
- ActivatesimmunecellsviatheTLR7/TLR8MyD88-dependentsignalingpathwayandleadstotheinductionofNF-κB[4].
- NLRP3/NALP3inflammasomeactivator,independentofTLRsandRIG-I[8].
- Upregulatoroftheopioidgrowthfactorreceptor[12].
- Usedinthetreatmentofskinlesionssuchasherpessimplexvirus[16].
ProductReferences
- ModulationofTH1andTH2cytokineproductionwiththeimmuneresponsemodifiers,R-848andimiquimod:T.L.Wagner,etal.;CellImmunol.191,10(1999)
- AdjuvantactivitiesofimmuneresponsemodifierR-848:comparisonwithCpGODN:J.P.Vasilakos,etal.;CellImmunol.204,64(2000)
- TheimmuneresponsemodifierresiquimodmimicsCD40-inducedBcellactivation:G.A.Bishop,etal.;Cell.Immunol.208,9(2001)
- Smallanti-viralcompoundsactivateimmunecellsviatheTLR7MyD88-dependentsignalingpathway:H.Hemmi,etal.;Nat.Immunol. 3,196(2002)
- HumanTLR7orTLR8independentlyconferresponsivenesstotheantiviralcompoundR-848:M.Jurk,etal.;Nat.Immunol. 3,499(2002)
- SyntheticTLRagoNISTsrevealfunctionaldifferencesbetweenhumanTLR7andTLR8:K.B.Gorden,etal.;J.Immunol.174,1259(2005)
- TLRagonistsasvaccineadjuvants:comparisonofCpGODNandResiquimod(R-848):R.D.Weeratna,etal.;Vaccine 23,5263(2005)
- BacterialRNAandsmallantiviralcompoundsactivatecaspase-1throughcryopyrin/Nalp3:T.D.Kanneganti,etal.;Nature440,233(2006)
- AdditiveeffectsofCpGODNandR-848asadjuvantsonaugmentingimmuneresponsestoHBsAgvaccination:R.Ma,etal.; BBRC361,537(2007)
- Resiquimodandotherimmuneresponsemodifiersasvaccineadjuvants:M.A.Tomai,etal.;ExpertRev.Vaccines6,835(2007)(Review)
- TheantiviralactivityofToll-likereceptor7and7/8agonists:R.L.Miller,etal.;DrugNewsPerspect.21,69(2008)(Review)
- Imiquimodupregulatestheopioidgrowthfactorreceptortoinhibitcellproliferationindependentofimmunefunction:I.S.Zagon,etal.;Exp.Biol.Med.233,968(2008)
- TargetingToll-likereceptor7/8enhancesuptakeofapoptoticleukemiccellsbymonocyte-deriveddendriticcellsbutinterfereswithsubsequentcytokine-inducedmaturation:W.vandenAncker,etal.;CancerImmunol.Immunother.60,37(2011)
- TreatmentwiththeTLR7agonistR848inducesregulatoryT-cell-mediatedsuppressionofestablishedasthmasymptoms:L.P.Van,etal.;Eur.J.Immunol.41,1992(2011)
- R-848triggerstheexpressionofTLR7/8andsuppressesHIVreplicationinmonocytes:H.Nian,etal.;BMCInfect.Dis.12,5(2012)
- Resiquimod|atopicaldrugforviralskinlesionsandskincancer:T.Meyer,etal.;ExpertOpin.Investig.Drugs22,149(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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