Adipogen/Quizartinib/SYN-1003-M050/50 mg
商品编号：
SYN-1003-M050
品牌：
Adipogen Inc
市场价：
¥19220.00
美元价：
11532.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AC220 |
| ProductType | Chemical |
| Properties | |
| Formula | C29H32N6O4S |
| MW | 560.7 |
| CAS | 950769-58-1 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol.=""> |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:PDGFR|KinaseGroup:RTK|Substrate:Tyrosine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | MKGMVQKQNTXMPT-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Quizartinib(AC220)isasecond-generationFLT3inhibitorthathasshownpromisingactivityinAMLinPhaseIIclinicaltrials.Itinhibitsmutantandwild-typeFLT3invivoat0.1and0.5µM,respectively,andhasshownfavorableactivityandtolerabilityinphaseIandIItrialsinacutemyeloidleukemia,withQTprolongationasthedose-limitingtoxicity.Recently,AC220hasalsobeenshowntobeaneffectiveinhibitorofATP-bindingcassette(ABC)proteinsABCB1(P-glycoprotein)andABCG2(breastcancerresistanceprotein).QuizartinibinhibitedtransportoffluorescentABCG2andABCB1substratesinABCG2-andABCB1-overexpressingcellsinaconcentration-dependentmanner,from0.1to5µMandfrom0.5to10µM,respectively,andinhibited[125I]-IAAPphotolabelingofABCG2andABCB1withIC(50)valuesof0.07and3.3µM,respectively.
ProductReferences
- AC220isauniquelypotentandselectiveinhibitorofFLT3forthetreatmentofacutemyeloidleukemia(AML):P.P.Zarrinkar,etal.;Blood114,2984(2009)
- 3-Phenyl-1H-5-pyrazolylamine-basedderivativesaspotentandefficaciousinhibitorsofFMS-liketyrosinekinase-3(FLT3):J.T.Hsu,etal.;Bioorg.Med.Chem.Lett.22,4654(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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