Adipogen/PP1/AG-CR1-3562-M005/5 mg
商品编号：
AG-CR1-3562-M005
品牌：
Adipogen Inc
市场价：
¥2600.00
美元价：
1560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine |
| ProductType | Chemical |
| Properties | |
| Formula | C16H19N5 |
| MW | 281.4 |
| CAS | 172889-26-8 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO.Slightlysolubleinethanol. |
| InChiKey | ZVPDNRVYHLRXLX-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- HighlypotentandselectiveScrfamilytyrosinekinaseinhibitor[1,2,6,9].
- Showsanti-RascancerpotentialbyblockingRas-inducedactivationofPAK1[4].
- Antitumorcompound[3,4,5,7].
- RIP2inhibitor[9].
- BlocksTGF-β-mediatedcellularresponses[8,10].
ProductReferences
- Discoveryofanovel,potent,andSrcfamily-selectivetyrosinekinaseinhibitor.StudyofLck-andFynT-dependentTcellactivation:J.H.Hanke,etal.;J.Biol.Chem.271,695(1996)
- Srcfamily-selectivetyrosinekinaseinhibitor,PP1,inhibitsbothFcepsilonRI-andThy-1-mediatedactivationofratbasophilicleukemiacells:M.Amoui,etal.;Eur.J.Immunol.27,1881(1997)
- LckassociateswithandisactivatedbyKitinasmallcelllungcancercellline:inhibitionofSCF-mediatedgrowthbytheSrcfamilykinaseinhibitorPP1:G.W.Krystal,etal.;CancerRes.58,4660(1998)
- Ananti-RascancerpotentialofPP1,aninhibitorspecificforSrcfamilykinases:invitroandinvivostudies:H.He,etal.;CancerJ.6,243(2000)
- ThekinaseinhibitorPP1blockstumOrigenesisinducedbyREToncogenes:F.Carlomagno,etal.;CancerRes.62,1077(2002)
- Thespecificitiesofproteinkinaseinhibitors:anupdate:J.Bain,etal.;Biochem.J.371,199(2003)
- TheSrc-selectivekinaseinhibitorPP1alsoinhibitsKitandBcr-Abltyrosinekinases:L.Tatton,etal.;J.Biol.Chem.278,4847(2003)
- Srcactivationisnotnecessaryfortransforminggrowthfactor(TGF)-beta-mediatedepithelialtomesenchymaltransitions(EMT)inmammaryepithelialcells.PP1directlyinhibitsTGF-betareceptorsIandII:M.Maeda,etal.;J.Biol.Chem.281,59(2006)
- Theselectivityofproteinkinaseinhibitors:afurtherupdate:J.Bain,etal.;Biochem.J.408,297(2007)
- TheSrcfamilykinaseinhibitorsPP2andPP1blockTGF-beta1-mediatedcellularresponsesbydirectanddifferentialinhibitionoftypeIandtypeIITGF-betareceptors:H.Ungefroren,etal.;Curr.CancerDrugTargets11,524(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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