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Adipogen/Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile)/IAX-200-021-M005/5 mg
![Adipogen/Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile)/IAX-200-021-M005/5 mg](https://www.ebiomall.cn/images/adipogen/iax-200-021_poly_ic_schematic_structure_correct.png)
| ProductDetails | |
|---|---|
| Synonyms | Polyinosinic-polycytidylicacid,potassiumsalt(poly(I:C)) |
| ProductType | Chemical |
| Properties | |
| MW | Highmolecularweight(>1.5kb). |
| CAS | 31852-29-6 |
| PurityChemicals | ≥99% |
| Reconstitution | Justbeforeuse,prepareastocksolutioninendotoxin-freeandsterileddWater(Cat.No.:IAX-900-002),orPBS(Cat.No.:IAX-900-001). |
| Formulation | Lyophilized.Sterile. |
| BIOLOGicalActivity | ActivatesTLR3,MDA5/HelicardandRIG-I.Optimalworkingconcentrationdependsupontargetreceptoraccessibility,number,density,aswellascelltype,andthereforeneedstobedeterminedforeachapplication.Recommendedconcentrationrange:invitro:0.5-10μg/ml;invivo:5mg/kg. |
| EndotoxinContent | <0.002eu g=""> |
| Declaration | ManufacturedbyInnaxon. |
| OtherProductData | Contains: 2mgand5mgsizesinclude1.5mlddWaterEndotoxin-free(sterile)(Cat.No.:IAX-900-002-LD15).10mgsizeincludes10mlddWaterEndotoxin-free(sterile)(Cat.No.:IAX-900-002-L010). |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Avoidfreeze/thawcycles. Afterreconstitution,preparealiquotsandkeepaqueousstocksolutionsfor1dayat4°Corstoreat-20°C(shelf-life6months). |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Toll-likereceptor(TLR)3isanendosomalTLRthatmediatesimmuneresponsesagainstviralinfectionsuponactivationbyitsliganddouble-strandedRNA,areplicationintermediateofmostviruses.TLR3isexpressedwidelyinthebodyandactivatesboththeinnateandadaptiveimmunesystems.Toll-likereceptor3(TLR3),melanomadifferentiation-associatedgene5(MDA5),andretinoicacid-inducIBLegene-I(RIG-I),allsensorsofdouble-strandedRNA(dsRNA)arepotentinducersofantiviralactivity.dsRNAsensoractivation-e.g.bypoly(I:C)-inducespro-inflammatoryTNF-αandantiviralIFN-β,butcanalsoenhancetheexpressionofpro-apoptoticproteins.Recently,poly(I:C)-inducedcelldeathrecentlygainedconsiderableattentionasatooltostudythe"Ripoptosome"or"Necrosome"complex,anovelintracellularsignalingcomplex,thoughttoinduceregulatednecrosis,alsocalled"Necroptosis".
- The"complexities"oflifeanddeath:Deathreceptorsignallingplatforms:L.S.Dickens,etal.Exp.CellRes.18,1269(2012)
- InhibitorofapoptosisproteinslimitRIP3kinase-dependentinterleukin-1activation:J.E.Vince,etal.Immunity36,215(2012)
- "Necrosome"-inducedinflammation:mustcellsdieforit?D.Wallach,etal.;TrendsImmunol.32,505(2011)
- Pickyourpoison:theRipoptosome,acelldeathplatformregulatingapoptosisandnecroptosis:M.Feoktistova,etal.;CellCycle11,460(2012)
- Ripoptosome:anovelIAP-regulatedcelldeath-signallingplatform:G.Imre,etal.;Mol.CellBiol.3,324(2011)
- IAPs:guardiansofRIPK1:M.Darding&P.Meier;CellDeathDiffer.19,58(2012)
- TheRipoptosome:deathdecisioninthecytosol:M.J.Bertrand&P.Vandenabeele;Mol.Cell43,323(2011)
- cIAPsblockRipoptosomeformation,aRIP1/caspase-8containingintracellularcelldeathcomplexdifferentiallyregulatedbycFLIPisoforms:M.Feoktistova,etal.;Mol.Cell43,449(2011)
- TheRipoptosome,asignalingplatformthatassemblesinresponsetogenotoxicstressandlossofIAPs:T.Tenev,etal.;Mol.Cell43,432(2011)
- ProapoptoticsignallingthroughToll-likereceptor-3involvesTRIF-dependentactivationofcaspase-8andisunderthecontrolofinhibitorofapoptosisproteinsinmelanomacells:A.Weber,etal.;CellDeathDiffer.17,942(2010)
- TLR3/TICAM-1signalingintumorcellRIP3-dependentnecroptosis:T.Seya,etal.;Oncoimmunology1,917(2012)
