Adipogen/PK 11195/AG-CR1-0008-M010/10 mg
商品编号：
AG-CR1-0008-M010
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide |
| ProductType | Chemical |
| Properties | |
| Formula | C21H21ClN2O |
| MW | 352.9 |
| CAS | 85532-75-8 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solublein100%ethanol,methanol,DMSOordichloromethane;insolubleinwater. |
| InChiKey | RAVIZVQZGXBOQO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SelectiveperipheralbenzodiazepineantagoNIST[1,2].
- Apoptosisenhancer[3,5,8].
- Glucose-inducedinsulinsecretioninhibitor[4].
- Inducesmitochondriacytochromecrelease[6].
- Anticancercompound[7].
- Antiproliferative[9].
- Pharmacologicaltoolinautophagy[10].
ProductReferences
- Differentiationbetweentwoligandsforperipheralbenzodiazepinebindingsites,[3H]RO5-4864and[3H]PK11195,byThermodynamicstudies:G.LeFuretal.;LifeSci.33,449(1983)
- Dihydropyridineandperipheraltypebenzodiazepinebindingsites:subcellulardistributionandmolecularsizedetermination:A.Dobleetal.;Eur.J.Pharmacol.119,153(1985)
- PK11195,aligandofthemitochondrialbenzodiazepinereceptor,facilitatestheinductionofapoptosisandreversesBcl-2-mediatedcytoprotection:T.Hirschetal.;Exp.Cell.Res.241,426(1998)
- Inhibitionofglucose-inducedinsulinsecretionbyaperipheral-typebenzodiazepinereceptorligand(PK11195):D.Pujalte,etal.;NaunynSchmiedebergsArch.Pharmacol.362,46(2000)
- PK11195potentlysensitizestoapoptosisinductionindependentlyfromtheperipheralbenzodiazepinreceptor:R.A.Gonzalez-Polo,etal.;Oncogene24,7503(2005)
- Peripheralbenzodiazepinereceptorligand,PK11195inducesmitochondriacytochromecreleaseanddissipationofmitochondriapotentialviainductionofmitochondriapermeabilitytransition:J.Li,etal.;Eur.J.Pharmacol.560,117(2007)
- ThepotentialanticanceragentPK11195inducesapoptosisirrespectiveofp53andATMstatusinchroniclymphocyticleukemiacells:A.F.Santidrianetal.;Haematologica92,1631(2007)
- ModulationofintracellularCa2+signallinginHeLacellsbytheapoptoticcelldeathenhancerPK11195:M.Campanellaetal.;Biochem.Pharmacol.76,1628(2008)
- AntiproliferativeeffectofperipheralbenzodiazepinereceptorantagonistPK11195inratmammarytumorcells:S.Mukhopadhyayetal.;Mol.Cell.Biochem.340,203(2010)
- Ca2+-dependentautophagyisenhancedbythepharmacologicalagentPK11195:Pharmacologicaltoolsinautophagy:A.Gastaldello,etal.;Autophagy6607(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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