Adipogen/PJ-34/AG-CR1-0100-M005/5 mg
商品编号：
AG-CR1-0100-M005
品牌：
Adipogen Inc
市场价：
¥1300.00
美元价：
780.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide.HCl |
| ProductType | Chemical |
| Properties | |
| Formula | C17H17N3O2.HCl |
| MW | 295.2.36.5 |
| CAS | 344458-15-7 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetolightbrownpowder. |
| Solubility | SolubleinDMSOorwater. |
| Identity | Identitydeterminedby1H-NMRandMS. |
| InChiKey | RURAZZMDMNRXMI-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Hygroscopic. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,watersolublepoly(ADP-ribose)polymerase(PARP)inhibitor.
- Inhibitsperoxynitrite-inducedcellnecrosis.
- Showssignificant,dose-dependentanti-inflammatoryeffectsinavarietyoflocalinflammationmodels.
- Providescardioprotectionbydecreasingmyocardialinfarctsize.
- Showsprotectiveeffectsinmodelsofstroke.
- Suppressescellgrowthinlivercancercells.
ProductReferences
- Diabeticendothelialdysfunction:theroleofpoly(ADP-ribose)polymeraseactivation:F.GarciaSoriano,etal.;Nat.Med.7,108(2001)
- ProtectiveeffectsofPJ34,anovel,potentinhibitorofpoly(ADP-ribose)polymerase(PARP)ininvitroandinvivomodelsofstroke:G.E.ABDelkarim,etal.;Int.J.Mol.Med.7,255(2001)
- Anti-inflammatoryeffectsofanovel,potentinhibitorofpoly(ADP-ribose)polymerase:J.G.Mabley,etal.;Inflamm.Res.50,561(2001)
- Pharmacologicinhibitionofpoly(adenosinediphosphate-ribose)polymerasemayrepresentanoveltherapeuticapproachinchronicheartfailure:P.Pacher,etal.;J.Am.Coll.Cardiol.40,1006(2002)
- Novelphenanthridinoneinhibitorsofpoly(adenosine5"-diphosphate-ribose)synthetase:potentcytoprotectiveandantishockagents:P.Jagtap,etal.;Crit.CareMed.30,1071(2002)
- MyocardialprotectionbyPJ34,anovelpotentpoly(ADP-ribose)synthetaseinhibitor:R.Faro,etal.;Ann.Thorac.Surg.73,575(2002)
- PJ34,aninhibitorofPARP-1,suppressescellgrowthandenhancesthesuppressiveeffectsofcisplatininlivercancercells:Oncol.Rep.20,567(2008)
- TheroleofPARPactivationinglutamate-inducednecroptosisinHT-22cells:X.Xu,etal.;BrainRes.1343,206(2010)
- Renalhypoperfusionandimpairedendothelium-dependentvasodilationinananimalmodelofVILI:theroleoftheperoxynitrite-PARPpathway:R.Vaschetto,etal.;Crit.Care14,R45(2010)
- Effectofparthanatosonropivacaine-induceddamageinSH-SY5Ycells:T.Zheng,etal.;Clin.Exp.Pharmacol.Physiol.44,586(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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