Adipogen/Piperlongumine/AG-CN2-0024-M010/10 mg
商品编号：
AG-CN2-0024-M010
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Piplartine;5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone |
| ProductType | Chemical |
| Properties | |
| Formula | C17H19NO5 |
| MW | 317.3 |
| CAS | 20069-09-4 |
| Source/HostChemicals | IsolatedfromPiperlongumroots. |
| PurityChemicals | ≥97% |
| Appearance | Whitecrystals. |
| Solubility | SolubleinDMSO,ethanol,methanolanddimethylformamide. |
| InChiKey | VABYUUZNAVQNPG-BQYQJAHWSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cytotoxicagainsttumorcelllines[3,4,5].
- Inducesnecrosisandapoptosisincancercells[5,9,12].
- Showsanti-plateletaggregationactivitypossIBLybyinhibitionofcyclooxgenaseactivityandadecreaseinthromboxaneA2formation[4,6,10].
- Showssignificantanxiolyticandantidepressantactivities[7].
- PromotesADIpogenesisof3T3-L1cells[8].
- Inducesinvivoandinvitromutagenicityineukaryoticmodels[11].
- SelectivelykillscancercellsbytargetingthestressresponsetoROS[12].
- Showsinvitroschistosomicidalactivity[13].
ProductReferences
- AlkaloidsofPiperlongumLinn.I.Structureandsynthesisofpiperlongumineandpiperlonguminine:A.Chatterjee&C.PDutta;Tetrahedron23,1769(1967)
- CytotoxicpyridonealkaloidsfromtheleavesofPiperaborescens:C.Y.Duh,etal.;J.Nat.Prod.53,1575(1990)
- Antiproliferativeeffectsoftwoamides,piperineandpiplartine,fromPiperspecies:D.P.Bezerra,etal.;Z.Naturforsch.C60,539(2005)
- Newcytotoxiccyclobutanoidamides,anewfuranoidlignanandanti-plateletaggregationconstituentsfromPiperarborescens:I.L.Tsai,etal.;PlantaMed.71,535(2005)
- Piplartineinducesinhibitionofleukemiacellproliferationtriggeringbothapoptosisandnecrosispathways:D.P.Bezerra,etal.;Toxicol.InVitro21,1(2007)
- Piperlongumine,aconstituentofPiperlongumL.,inhibitsrabbitplateletaggregationasathromboxaneA(2)receptorantagoNIST:M.Iwashita,etal.;Eur.J.Pharmacol.570,38(2007)
- Piplartine,anamidealkaloidfromPipertuberculatum,presentsanxiolyticandantidepressanteffectsinmice:F.F.CíceroBezerra,etal.;Phytomedicine14,605(2007)
- Effectsofamideconstituentsfrompepperonadipogenesisin3T3-L1cells:H.Zhang,etal.;Bioorg.Med.Chem.Lett.18,3272(2008)
- Piplartineinducescaspase-mediatedapoptosisinPC-3humanprostatecancercells:E.H.Kong,etal.;Oncol.Rep.20,785(2008)
- Antiplateleteffectsofpiplartine,analkamideisolatedfromPipertuberculatum:possibleinvolvementofcyclooxygenaseblockadeandantioxidantactivity:J.B.Fontenele,etal.;J.Pharm.Pharmacol.61,511(2009)
- Piplartineinducesgenotoxicityineukaryoticbutnotinprokaryoticmodelsystems:D.P.Bezerra,etal.;Mutat.Res.677,8(2009)
- SelectivekillingofcancercellsbyasmallmoleculetargetingthestressresponsetoROS:L.Raj,etal.;Nature475,231(2011)
- Schistosomamansoni:Invitroschistosomicidalactivityofpiplartine:J.Moraes,etal.;Exp.Parasitol.127,357(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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