Adipogen/Pioglitazone/AG-CR1-0067-M001/1 mg
商品编号：
AG-CR1-0067-M001
品牌：
Adipogen Inc
市场价：
¥400.00
美元价：
240.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl-2,4-thiazolidinedione |
| ProductType | Chemical |
| Properties | |
| Formula | C19H20N2O3S |
| MW | 356.4 |
| MerckIndex | 14:7452 |
| CAS | 111025-46-8 |
| PurityChemicals | ≥98%(1H-NMR). |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(2.5mg/ml)ordimethylformamide(DMF)(2.5mg/ml). |
| Identity | Determinedby1H-NMR. |
| InChiKey | HYAFETHFCAUJAY-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Thiazolidinedione(TZD)referencecompound[2,3].
- SelectivePPARγagoNIST. SelectivelyactivatesPPARγ-1[1,3].
- Anti-diabetic [3-5],decreasinginsulinresistanceinADIposetissue.
- Isaboutonetenthaspotentasrosiglitazone[1,2].
- Lipidmetabolismmodulator[6].
- Estrogensynthesisinhibitor[7].
- NF-κBinhibitor[8].
- Neuroprotective[9].
ProductReferences
- Activationofhumanperoxisomeproliferator-activatedreceptor(PPAR)subtypesbypioglitazone:J.Sakamoto,etal.;BBRC278,704(2000)
- ThePPARs:fromorphanreceptorstodrugdiscovery:T.M.Willson,etal.;J.Med.Chem.43,527(2000)
- Thestructure-activityrelationshipbetweenperoxisomeproliferator-activatedreceptorgammaagonismandtheantihyperglycemicactivityofthiazolidinediones:T.M.Willson,etal.;J.Med.Chem.39,665(1996)
- Anantidiabeticthiazolidinedioneisahighaffinityligandforperoxisomeproliferator-activatedreceptorgamma(PPARgamma):J.M.Lehmann,etal.;J.Biol.Chem.270,12953(1995)
- [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinedionesaspotentantihyperglycemicagents:B.C.Cantello,etal.;J.Med.Chem.37,3977(1994)
- Pioglitazone:beyondglucosecontrol:P.dePablos-Velasco;ExpertRev.Cardiovasc.Ther.8,1057(2010)Review
- RosiglitazoneandPioglitazoneInhibitEstrogenSynthesisinHumanGranulosaCellsbyInterferingwithAndrogenBindingtoAromatase:D.Seto-Young,etal.;Horm.Metab.Res.43,250(2011)
- Pioglitazonesuppressesthelipopolysaccharide-inducedproductionofinflammatoryfactorsinmousemacrophagesbyinactivatingNF-kappaB:C.Ao,etal.;CellBiol.Int.34,723(2010)
- Neuroprotectiveeffectsofpioglitazoneinaratmodelofpermanentfocalcerebralischemiaareassociatedwithperoxisomeproliferator-activatedreceptorgamma-mediatedsuppressionofnuclearfactor-κBsignalingpathway:H.L.Zhang,etal.;Neuroscience176,381(2011)
- Wnt/b-cateninsignalingmodulateshumanairwaysensitizationinducedbyb2-adrenoceptorstimulation:C.Faisy,etal.;PLoSOne9,e111350(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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