Adipogen/Pifithrin-α · hydrobromide/AG-CR1-0004-M005/5 mg
商品编号：
AG-CR1-0004-M005
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr, Pfithrin alpha |
| Product Type | Chemical |
| Properties | |
| Formula | C16H18N2OS . HBr |
| MW | 286.4 . 80.9 |
| CAS | 63208-82-2 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or 100% ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | HAGVCKULCLQGRF-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- p53 inhibitor [1, 2].
- Reversibly blocks p53-dependent transcriptional activation [2].
- Tool to combat side effects of cancer therapy [3].
- Apoptosis inhibitor [1, 2, 4].
Product References
- A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999)
- Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J. Biol. Chem. 279, 30195 (2004)
- Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999)
- Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio: D. Javelaud & F. Besancon; J. Biol. Chem. 277, 37949 (2002)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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