Adipogen/Piceatannol/AG-CN2-0086-M025/25 mg
商品编号：
AG-CN2-0086-M025
品牌：
Adipogen Inc
市场价：
¥2800.00
美元价：
1680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CCRIS9289;NSC365798;NSC622471;3,3",4,5"-Tetrahydroxy-trans-stilbene;3-Hydroxyresveratrol |
| ProductType | Chemical |
| Properties | |
| Formula | C14H12O4 |
| MW | 244.3 |
| CAS | 10083-24-6 |
| Source/HostChemicals | Synthetic.OriginallyisolatedfromEuphorbialagascae. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitetolightpinkcrystallinesolid. |
| Solubility | SolubleinDMSO,dimethylformamide,ethanol,methanol,acetoneorethylacetate.Slightlysolubleinwater. |
| InChiKey | CDRPUGZCRXZLFL-OWOJBTEDBC |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Widerangeoftyrosineandserine/threonineproteinkinaseinhibitor,includingSyk,p56lck,PKA,PKC,MLCK,CDPK,JNKandPI3K[1-3,9,14,15].
- InhibitsthetyrosinephosphorylationofSTAT3andSTAT5[4].
- Potentapoptosisinducer[5].
- Potentanticancercompound[6,10,16,17].
- SuppressesNF-kBactivationthroughIkBαkinaseinhibition[7].
- ActivatorofhumandeacetylaseSIRT1(sirtuin1)[8].
- Potentantioxidantwithanti-proliferative,anti-inflammatoryandcardioprotectiveproperties[10,14,15,17,19].
- Neuoprotective[11,14].
- ADIpogenesisinhibitor[18].
- Promotesglucoseuptake,AMPKphosphorylationandGLUT4translocation[20].
- Autophagyinducer[21]
ProductReferences
- Piceatannol(3,4,3",5"-tetrahydroxy-trans-stilbene)isanaturallyoccurringprotein-tyrosinekinaseinhibitor:R.L.Geahlen,etal.;BBRC165,241(1989)
- InhibitionofmastcellFcepsilonR1-mediatedsignalingandeffectorfunctionbytheSyk-selectiveinhibitor,piceatannol:J.M.Oliver,etal.;J.Biol.Chem.269,29697(1994)
- Inhibitionofeukaryoteserine/threonine-specificproteinkinasesbypiceatannol:B.H.Wang,etal.;PlantaMed.64,195(1998)
- DistinctmechanismsofSTATphosphorylationviatheinterferon-alpha/betareceptor.SelectiveinhibitionofSTAT3andSTAT5bypiceatannol:L.Su&M.David;J.Biol.Chem.275,12661(2000)
- Piceatannol,ahydroxylatedanalogofthechemopreventiveagentresveratrol,isapotentinducerofapoptosisinthelymphomacelllineBJABandinprimary,leukemiclymphoblasts:T.Wieder,etal.;Leukemia15,1735(2001)
- Piceatannol,anaturalanalogofresveratrol,inhibitsprogressionthroughtheSphaseofthecellcycleincolorectalcancercelllines:F.Wolter,etal.;J.Nutr.132,298(2002)
- PiceatannolinhibitsTNF-inducedNF-kappaBactivationandNF-kappaB-mediatedgeneexpressionthroughsuppressionofIkappaBalphakinaseandp65phosphorylation:K. Ashikawa,etal.;J.Immunol.169,6490(2002)
- SmallmoleculeactivatorsofsirtuinsextendSaccharomycescerevisiaeLifespan:K.T.Howitz,etal.;Nature425,191(2003)
- Piceatannolupregulatesendothelialhemeoxygenase-1expressionvianovelproteinkinaseCandtyrosinekinasepathways:B.S.Wung,etal.;Pharmacol.Res.53,113(2006)
- Antioxidantactivityofresveratrol,piceatannoland3,3",4,4",5,5"-hexahydroxy-trans-stilbeneinthreeleukemiacelllines:Z.Ovesna,etal.;Oncol.Rep.16,617(2006)
- Protectiveeffectsofpiceatannolagainstbeta-amyloid-inducedneuronalcelldeath:H.J.Kim,etal.;Ann.NYAcad.Sci.1095,473(2007)
- Piceatannolinhibitsmelanogenesisbyitsantioxidativeactions:T.Yokozawa&Y.J.Kim;Biol.Pharm.Bull.30,2007(2007)
- InductionofapoptosisbypiceatannolinhumanleukemicU937cellsthroughdown-regulationofBcl-2andactivationofcaspases:Y.H.Kim,etal.;Oncol.Rep.19,961(2008)
- Piceatannolattenuates4-hydroxynonenal-inducedapoptosisofPC12cellsbyblockingactivationofc-JunN-terminalkinase:Y.J.Jang,etal.;Ann.NYAcad.Sci.1171,176(2009)
- Phosphoinositide3-kinaseisanoveltargetofpiceatannolforinhibitingPDGF-BB-inducedproliferationandmigrationinhumanaorticsmoothmusclecells:K.H.Choi,etal.;Cardiovasc.Res.85,836(2010)
- Piceatannolinhibitsmigrationandinvasionofprostatecancercells:possIBLemediationbydecreasedinterleukin-6signaling:G.T.Kwon,etal.;J.Nutr.Biochem.23,228(2012)
- BIOLOGicalactivityofpiceatannol:leavingtheshadowofresveratrol:H.Piotrowska,etal.;Mutat.Res.750,60(2012)(Review)
- Piceatannol,naturalpolyphenolicstilbene,inhibitsadipogenesisviamodulationofmitoticclonalexpansionandinsulinreceptor-dependentinsulinsignalinginearlyphaseofdifferentiation:J.Y.Kwon,etal.;J.Biol.Chem.287,11566(2012)
- Antiproliferativeandanti-invasiveeffectofpiceatannol,apolyphenolpresentingrapesandwine,againsthepatomaAH109Acells:Y.Kita,etal.; J.Biomed.Biotechnol.2012,672416(2012)
- Piceatannol,aresveratrolderivative,promotesglucoseuptakethroughglucosetransporter4translocationtoplasmamembraneinL6myocytesandsuppressesbloodglucoselevelsintype2diabeticmodeldb/dbmice:M.Minakawa,etal.;BBRC422,469(2012)
- Pro-autophagicpolyphenolsreducetheacetylationofcytoplasmicproteins:F.Pietrocola,etal.;CellCycle11,3851(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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