![Adipogen/PI-1840 [Proteasome Inhibitor]/AG-CR1-3675-M001/1 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-3675.png)
Adipogen/PI-1840 [Proteasome Inhibitor]/AG-CR1-3675-M001/1 mg
商品编号：
AG-CR1-3675-M001
品牌：
Adipogen Inc
市场价：
¥500.00
美元价：
300.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N-(1-Methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxADIazol-5-yl]methyl]-acetamide |
| ProductType | Chemical |
| Properties | |
| Formula | C22H26N4O3 |
| MW | 394.5 |
| CAS | 1401223-22-0 |
| PurityChemicals | ≥98% |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO(30mg/ml)orethanol(20mg/ml).Poorlysolubleinaqueoussolutions. |
| OtherProductData | Note:Warmingandsonicationmayberequiredwhendissolvingthecompoundinthesolventofchoice.Stocksolutionsarestableforatleast1monthwhenstoredat-20°C. |
| InChiKey | ZVVXAODXPVWGMF-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Highlypotent,selectiveandrapidlyreversIBLenon-covalentproteasomeinhibitor.
- Targetsthechymotrypsin-likeβ5-subunitoftheconstitutive20Sproteasome(IC50=27nM),withminimalcross-reactivityonthetrypsin-like(β2)andcaspase-like/postglutamyl-peptide-hydrolysis-like(β1)proteolyticactivity(IC50=>100μM,forboth).Exhibitedover100-foldselectivityfortheconstitutive20Sproteasomeovertheimmunoproteasome.
- Anticancercompound.
- Invitro,inducestheaccumulationofproteasomesubstratesp27,Bax,andIκB-α,inhibitssurvivalpathwaysandviabilityandinducesapoptosisinintactcancercells.
- ShowntoinhibittumorgrowthinmiceofMDA-MB-231breasttumors.
ProductReferences
- Oxadiazole-isopropylamidesaspotentandnoncovalentproteasomeinhibitors:S.Ozcan,etal.;J.Med.Chem.56,3783(2013)
- DiscoveryofPI-1840,anovelnoncovalentandrapidlyreversibleproteasomeinhibitorwithanti-tumoractivity:A.Kazi,etal.;J.Biol.Chem.289,11906(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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