Adipogen/Phorbol 12-myristate 13-acetate/AG-CN2-0010-M001/1 mg
商品编号：
AG-CN2-0010-M001
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PMA;TPA;12-O-Tetradecanoylphorbol13-acetate |
| ProductType | Chemical |
| Properties | |
| Formula | C36H56O8 |
| MW | 616.8 |
| MerckIndex | 14:7332 |
| CAS | 16561-29-8 |
| RTECS | QH4377000 |
| Source/HostChemicals | Semisynthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,methanol,100%ethanol,acetone,etherordimethylformamide;almostinsolubleinaqueousbuffers. |
| OtherProductData | Stocksolutionsarestableforupto3monthsat-20°C. |
| InChiKey | PHEDXBVPIONUQT-RGYGYFBISA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Mostcommonly-usedphorbolester[1,2].
- BindstoandactivatesproteinkinaseC(PKC)atnMconcentrations[1,2,9].
- Inducescellgrowtharrestthroughavarietyofpathwaysincludingthemitogen-activatedproteinkinases(MAPKs),p38andc-JunN-terminalkinase(JNK)pathwaysmediatedbycyclindependentkinase(CDK)inhibitorssuchasp21WAF1/CIP1,p27KIP1,p15andp16.
- Potentmouseskintumorpromoter[3,4].
- PromoterofinducIBLeNOS(iNOS;NOSII)[5].
- Apoptosisinducer[6].
- Potentialeffectivecancertherapeuticagent[7,8].
- Inhibitorofanti-lipolyticactivityofinsulin[10].
ProductReferences
- Invitrostudiesonthemodeofactionofthephorbolesters,potenttumorpromoters:part1:P.M.Blumberg;Crit.Rev.Toxicol.8,153(1980)
- Invitrostudiesonthemodeofactionofthephorbolesters,potenttumorpromoters:part2:P.M.Blumberg;Crit.Rev.Toxicol.8,199(1981)
- Skintumorpromotionbyphorbolestersisatwo-stageprocess:G.Fürstenberger,etal.;PNAS78,7722(1981)
- Phorbolestersassignaltransducersandtumorpromoters:M.Castagna;Biol.Cell59,3(1987),Review
- Phorbolestersinducenitricoxidesynthaseactivityinrathepatocytes.Antagonismwiththeinductionelicitedbylipopolysaccharide:S.Hortelano,etal.;J.Biol.Chem.267,24937(1992)
- PhorbolesterinducesapoptosisinHL-60promyelocyticleukemiacellsbutnotinHL-60PETmutant:D.E.Macfarlane&P.S.O"Donnel;Leukemia7,1846(1993)
- Effectofintravenousinfusionsof12-O-tetradecanoylphorbol-13-acetate(TPA)inpatientswithmyelocyticleukemia:Preliminarystudiesontherapeuticefficacyandtoxicity:T.H.Zheng,etal.;PNAS95,5357(1998)
- 12-O-Tetradecanoylphorbol-13-acetate(TPA)-inducedincreaseindepressedwhitebloodcellcountsinpatientstreatedwithcytotoxiccancerchemotherapeuticdrugs:T.H.Zheng,etal.;PNAS95,5362(1998)
- CharacterizationofphorbolestersactivityonindividualmammalianproteinkinaseCisoforms,usingtheyeastphenotypicassay:L.Saraiva,etal.;Eur.J.Pharmacol.491,101(2004)
- Phorbol12-myristate13-acetateinhibitstheantilipolyticactionofinsulin,probablyviatheactivityofproteinkinaseCε:J.Nakamura;Eur.J.Pharmacol.648,188(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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