Adipogen/PFI-1/SYN-3041-M050/50 mg
商品编号：
SYN-3041-M050
品牌：
Adipogen Inc
市场价：
¥8420.00
美元价：
5052.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide; PF-06405761 |
| Product Type | Chemical |
| Properties | |
| Formula | C16H17N3O4S |
| MW | 347.4 |
| CAS | 1403764-72-6 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: BET, BrD4 | Kinase Group: N/A | Substrate: N/A Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | TXZPMHLMPKIUGK-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
PFI-1 efficiently and selectively blocks the interaction of BET BRDs with acetylated histone tails. PFI-1 displaces histone 4 peptide acetylated at lysines K5, K8, K12 and K16 (H4K5acK8acK12acK16ac) with a potency (IC50) of 220nM for BRD4 and 98nM for BRD2. Exposure of sensitive cell lines with PFI-1 results in G1 cell cycle arrest, down-regulation of MYC expression as well as induction of apoptosis and induces differentiation of primary leukaemic blasts.
Product References
- Selective inhibition of BET bromodomains: P. Filippakopoulos, et al.; Nature 468, 1067 (2010)
- PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains: S. Picaud, et al.; Cancer Res. 73, 3336 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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