Adipogen/PF-4618433/SYN-1163-M010/10 mg
商品编号：
SYN-1163-M010
品牌：
Adipogen Inc
市场价：
¥13060.00
美元价：
7836.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PF4618433 |
| ProductType | Chemical |
| Properties | |
| Formula | C24H27N7O2 |
| MW | 445.5 |
| CAS | 1166393-85-6 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:PYK2-FAK|KinaseGroup:PTK|Substrate:Tyrosine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | NJARPUHZDSAXPL-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
PotentandselectivePYK2inhibitor.PF-4618433showsimprovedPYK2potency,reducedp38activity,andsuperioroverallselectivityrelativetotheprototypeBIRB796.Inthefunctionalosteogenesisassays,culturestreatedwithincreasingconcentrationsofPF-4618433startingatday1andmaintainedthroughoutshowedadose-dependentincreasesinbothalkalinephosphataseactivityandmineralization.
ProductReferences
- Structuralcharacterizationofproline-richtyrosinekinase2(PYK2)revealsaunique(DFG-out)conformationandenablesinhibitordesign:S.Han,etal.;J.Biol.Chem.284,13193(2009)
- Identificationofnovelseriesofpyrazoleandindole-ureabasedDFG-outPYK2inhibitors:S.K.Bhattacharya,etal.;Bioorg.Med.Chem.Lett.22,7523(2012)
- Non-canonicalpathwayinducedbyWnt3aregulatesb-cateninviaPyk2indifferentiatinghumanneuralProgenitorcells:V.A.N.Talabattula,etal.;BBRC491,40(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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