Adipogen/PF-431396/SYN-1063-M010/10 mg
商品编号：
SYN-1063-M010
品牌：
Adipogen Inc
市场价：
¥4540.00
美元价：
2724.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | PF431396 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H21F3N6O3S |
| MW | 506.5 |
| CAS | 717906-29-1 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PYK2 | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | POJZIZBONPAWIV-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Potent FAK and PYK2 inhibitor. PF431396 has an IC(50) of 31nM against the recombinant PYK2 enzyme.
Product References
- Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis: L. Buckbinder, et al.; PNAS 104, 10619 (2007)
- Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design: S. Han, et al.; J. Biol. Chem. 284, 13193 (2009)
- B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading: K.W. Tse, et al.; J. Biol. Chem. 284, 22865 (2009)
- Emerging targets in osteoporosis disease modification: J.G. Allen, et al.; J. Med. Chem. 53, 4332 (2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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