Adipogen/PF-2545920/AG-CR1-3636-M025/25 mg
商品编号：
AG-CR1-3636-M025
品牌：
Adipogen Inc
市场价：
¥9000.00
美元价：
5400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-(4-(1-Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)-phenoxymethyl)quinoline;MP-10 |
| ProductType | Chemical |
| Properties | |
| Formula | C25H20N4O |
| MW | 392.5 |
| CAS | 898562-94-2 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorethanol.Insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | AZEXWHKOMMASPA-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentandselectivephosphodiesterase10A(PDE10A)inhibitor(IC50=1.26nM)invitroandinvivo.PDE10AisacGMPandcAMPdegrADIngPDEisozymewithneurologicalimportanceandwasshowntobeimplicatedintheregulationofenergyhomeostasis.InhibitionofPDE10AleadstointerferenceofthebreakdownofthesecondarymessengercAMPandcGMP.
- Anti-psychoticagent.Usefulforthetreatmentofschizophrenia.
- Anticanceragent.InhibitscolontumorcellgrowthforwhichhighlevelsofPDE10Ahavebeenreported.
- Antiobesityandantidiabeticagent.Inducesbrowninginwhiteadiposetissue(WAT).
ProductReferences
- Discoveryofanovelclassofphosphodiesterase10Ainhibitorsandidentificationofclinicalcandidate2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline(PF-2545920)forthetreatmentofschizophrenia:P.R.Verhoest,etal.;J.Med.Chem.52,5188(2009)
- Phosphodiesterase10Ainhibitoractivityinpreclinicalmodelsofthepositive,cognitive,andnegativesymptomsofschizophrenia:S.M.Grauer,etal.;J.Pharmacol.Exp.Ther.331,574(2009)
- Effectsofphosphodiesterase10inhibitiononstriatalcyclicAMPandperipheralphysiologyinrats:A.Torremans,etal.;ActaNeurobiol.Exp.70,13(2010)
- Phosphodiesterase10Ainhibitor,MP-10(PF-2545920),producesgreaterinductionofc-FosindopamineD2neuronsthaninD1neuronsintheneostriatum:J.M.Wilson,etal.;Neuropharmacol.99,379(2015)
- β-cateninnucleartranslocationincolorectalcancercellsissuppressedbyPDE10Ainhibition,cGMPelevation,andactivationofPKG:K.Lee,etal.;Oncotarget7,5353(2016)
- AnovelThermoregulatoryroleforPDE10Ainmouseandhumanadipocytes:M.K.Hankir,etal.;EMBOMol.Med.8,796(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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