Adipogen/PF-0477736/SYN-1174-M050/50 mg
商品编号：
SYN-1174-M050
品牌：
Adipogen Inc
市场价：
¥13940.00
美元价：
8364.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PF0477736 |
| ProductType | Chemical |
| Properties | |
| Formula | C22H25N7O2 |
| MW | 419.5 |
| CAS | 952021-60-2 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:Chk1|KinaseGroup:CAMK|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | NDEXUOWTGYUVGA-LJQANCHMSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
AntagonizingtheChk1-mediatedcellcyclecheckpointshasemergedasanattractivetargetforanticancertherapy.IfChk1activityisblocked,DNA-damagedorspindle-disruptedcellswouldexitcellcyclearrestbeforefullrepairandsubsequentlyundergomitoticcatastropheorcelldeath.Chk1inhibitorsconsequentlyincreasethetherapeuticindexofDNA-damagingorantimitoticagentsaswell.PF-0477736isaselective,potentATP-competitiveChk1inhibitor,derivedfromPF-0394691,inhibitsChk1(Ki,0.49nM)andChk2(Ki,47nM)invitro.Intests,PF-0477736wasidentifiedasapotent,selectiveATP-competitivesmall-moleculeinhibitorthatinhibitsChk1withaKiof0.49nM.PF-0477736abrogatescellcyclearrestinducedbyDNAdamageandenhancescytotoxicityofclinicallyimportantchemotherapeuticagents,includinggemcitabineandcarboplatin.Inxenografts,PF-0477736enhancedtheantitumoractivityofgemcitabineinadose-dependentmanner.PF-0477736combinationswerewelltoleratedwithnoexacerbationofsideeffectscommonlyassociatedwithcytotoxicagents.
ProductReferences
- BreachingtheDNAdamagecheckpointviaPF-00477736,anovelsmall-moleculeinhibitorofcheckpointkinase1:A.Blasina,etal.;Mol.CancerTher.7,2394(2008)
- DNAdamagedetectionandrepairpathways-recentadvanceswithinhibitorsofcheckpointkinasesincancertherapy:S.Ashwell&S.Zabludoff;Clin.CancerRes.14,4032(2008)
- PF-00477736mediatescheckpointkinase1signalingpathwayandpotentiatesdocetaxel-inducedefficacyinxenografts:C.Zhang,etal.;Clin.CancerRes.15,4630(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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