Adipogen/Pepstatin A/AG-CP3-7001-M025/25 mg
商品编号：
AG-CP3-7001-M025
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA;ProcidinS735A;NSC272671 |
| ProductType | Chemical |
| Properties | |
| Formula | C34H63N5O9 |
| MW | 685.9 |
| Sequence | Iva-Val-Val-Sta-Ala-Sta |
| MerckIndex | 14:7147 |
| CAS | 26305-03-3 |
| RTECS | SC6155000 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO,methanoloraceticacid. |
| InChiKey | FAXGPCHRFPCXOO-LXTPJMTPSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Tight-binding,reversIBLe,highlyselectiveinhibitorofacidproteases(aspartylpeptidases),likepepsin,gastricsin,cathepsinEandD,renin,chymosin,bacterialasparticproteinasesandHIVproteases.
- Doesnotinhibitthiolproteases,neutralproteasesorserineproteases.
- WidelyusedasaresearchtoolinstudiesofproteasemechanismsandBIOLOGicalfunctions.
- Solubilizedγ-secretaseandretroviralproteaseinhibitor.
- Showsantibacterial,antifungalandantiparasiticactivity.
- Suppressesp53-dependentapoptosisinlymphoidcellsaswellasTNFα-inducedapoptosisinU937cells.
- Inhibitsdegradationofautophagiccargoinsideautophagolysosomes.
ProductReferences
- Pepstatin,anewpepsininhibitorproducedbyActinomycetes:H.Umezawa,etal.;J.Antibiot.(Tokyo)23,259(1970)
- InhibitionofcathepsinD-typeproteinaseofmacrophagesbypepstatin,aspecificpepsininhibitor,andothersubstances:M.H.McAdoo,etal.;Infect.Immun.7,655(1973)
- Modeofinhibitionofacidproteasesbypepstatin:J.Jr.Marciniszyn,etal.;J.Biol.Chem.251,7088(1976)
- Non-specificinhibitionofpressoragentsinvivobytherenininhibitorpepstatinA:A.A.Oldham,etal.;J.Hypertens.2,157(1984)
- Inhibitionofasparticproteasesbypepstatinand3-methylstatinederivativesofpepstatin.Evidenceforcollected-substrateenzymeinhibition:D.H.Rich,etal.;Biochemistry24,3165(1985)
- InhibitionofHIVreplicationincellculturebythespecificasparticproteaseinhibitorpepstatinA:K.vonderHelm,etal.;FEBSLett.247,349(1989)
- CathepsinDproteasemediatesprogrammedcelldeathinducedbyinterferon-gamma,Fas/APO-1andTNF-alpha:L.P.Deiss,etal.;EMBOJ.15,3861(1996)
- PepstatinA-sensitiveasparticproteasesinlysosomeareinvolvedindegradationoftheinvariantchainandantigen-processinginantigenpresentingcellsofmiceinfectedwithLeishmaniamajor:T.Zhang,etal.;BBRC276,693(2000)
- Linearnon-competitiveinhibitionofsolubilizedhumangamma-secretasebypepstatinAmethylester,L685458,sulfonamides,andbenzodiazepines:G.Tian,etal.;J.Biol.Chem.277,31499(2002)
- PepstatinA,anasparticproteinaseinhibitor,suppressesRANKL-inducedosteoclastdifferentiation:H.Yoshida,etal.;J.Biochem.139,583(2006)
- PepstatinAaltershostcellautophagicmachineryandleadstoadecreaseininfluenzaAvirusproduction:P.Matarrese,etal.;J.CellPhysiol.226,3368(2011)
- InhibitionofXMRVandHIV-1proteasesbypepstatinAandacetyl-pepstatin:K.Matuz,etal.;FEBSJ.279,3276(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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