Adipogen/PD-0173074/SYN-1176-M100/100 mg
商品编号：
SYN-1176-M100
品牌：
Adipogen Inc
市场价：
¥15120.00
美元价：
9072.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PD0173074 |
| ProductType | Chemical |
| Properties | |
| Formula | C28H41N7O3 |
| MW | 523.7 |
| CAS | 219580-11-7 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorethanol. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:VEGFR2-FGFR1|KinaseGroup:RTK|Substrate:Tyrosine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | DXCUKNQANPLTEJ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
PD173074isapotentFGFR1inhibitorwithIC(50)ofapproximately25nMandalsoinhibitsVEGFR2withanIC(50)of100-200nM.
ProductReferences
- SpecificinhibitorofFGFreceptorsignaling:FGF-2-mediatedeffectsonproliferation,differentiation,andMAPKactivationareinhibitedbyPD173074inoligodendrocyte-lineagecells:R.Bansal,etal.;J.Neurosci.Res.74,486(2003)
- Inhibitionoffibroblastgrowthfactorreceptor3inducesdifferentiationandapoptosisint(4;14)myeloma:S.Trudel,etal.;Blood103,3521(2004)
- 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea(PD173074),aselectivetyrosinekinaseinhibitoroffibroblastgrowthfactorreceptor-3(FGFR3),inhibitscellproliferationofbladdercancercarryingtheFGFR3genemutationalongwithup-regulationofp27/Kip1andG1/G0arrest:M.Miyake,etal.;J.Pharmacol.Exp.Ther.332,795(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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