Adipogen/PD 98,059/AG-CR1-0118-M010/10 mg
商品编号：
AG-CR1-0118-M010
品牌：
Adipogen Inc
市场价：
¥1900.00
美元价：
1140.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2"-Amino-3"-methoxyflavone |
| ProductType | Chemical |
| Properties | |
| Formula | C16H13NO3 |
| MW | 267.3 |
| CAS | 167869-21-8 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Yellowsolid. |
| Solubility | SolubleinanhydrousDMSO,methanolordichloromethane.Slightlysolubleinethanol. |
| InChiKey | QFWCYNPOPKQOKV-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Storesolutionsat-20°Cinthedark. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Highlyselective,reversIBLeandcellpermeableMEK(MAPkinasekinase)inhibitor [1-3,7].
- BlocksthephosphorylationandactivationoftheMAPkinasepathway[1-3,7].
- Tcellactivationinhibitor[4].
- Inhibitscellgrowthandcellproliferationofseveralcancercells[5,6,8].
ProductReferences
- Asyntheticinhibitorofthemitogen-activatedproteinkinasecascade:D.T.Dudley,etal.;PNAS92,7686(1995)
- InhibitionofMAPkinasekinaseblocksthedifferentiationofPC-12cellsinducedbynervegrowthfactor:L.Pang,etal.;J.Biol.Chem.270,13585(1995)
- PD098059isaspecificinhibitoroftheactivationofmitogen-activatedproteinkinasekinaseinvitroandinvivo:D.Alessi,etal.;J.Biol.Chem.270,27489(1995)
- InhibitionofTcellactivationbypharmacologicdisruptionoftheMEK1/ERKMAPkinaseorcalcineurinsignalingpathwaysresultsindifferentialmodulationofcytokineproduction:F.J.Dumont,etal.;J.Immunol.160,2579(1998)
- Aphosphatidylinositol3-kinaseinhibitorinducesasenescent-likegrowtharrestinhumandiploidfibroblasts:M.Tresini,etal.;CancerRes.58,1(1998)
- PD098059,aninhibitorofERK1activation,attenuatestheinvivoinvasivenessofheadandnecksquamouscellcarcinoma:C.Simon,etal.;Br.J.Cancer80,1412(1999)
- Specificityandmechanismofactionofsomecommonlyusedproteinkinaseinhibitors.S.P.Davies,etal.;Biochem.J.351,95(2000)
- Mitogen-activatedproteinkinasekinaseinhibitionenhancesnuclearproapoptoticfunctionofp53inacutemyelogenousleukemiacells: K.Kojima,etal.;CancerRes.67,3210(2007)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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