Adipogen/Paxilline/AG-CN2-0167-M005/5 mg
商品编号：
AG-CN2-0167-M005
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | BRN5317894;NSC658707 |
| ProductType | Chemical |
| Properties | |
| Formula | C27H33NO4 |
| MW | 435.6 |
| CAS | 57186-25-1 |
| RTECS | DJ2830000 |
| Source/HostChemicals | IsolatedfromPenicilliumsp. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSO,methanolorethanol. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBiOlinksK.K.withcourtesystrainfromTheKitasatoInstitute. |
| InChiKey | ACNHBCIZLNNLRS-UBGQALKQSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Tremorgenic[1].
- Potent,selectiveandreversIBLeinhibitorofhigh-conductancecalcium-activatedpotassium(BKCa)channels[2].
- Reversibleinhibitorofinositol1,4,5-trisphosphatereceptor(InsP(3))[3].
- Sarco/endoplasmicreticulumCa2+ATPase(SERCA)inhibitor[4].
- LiverXreceptor(LXRαandLXRβ;NR1H3andNR1H2)agoNISTinbiochemicalandinvitrocell-basedassays[5].
- Anticonvulsant[6].
- Apoptosisenhancer.CansensitizevariousgliomacellstoTRAIL-mediatedapoptosis[7].
- Showntoprotectneuronalcellsagainstglutamate-inducedcelldeath[8].
ProductReferences
- AnewtremorgenicmetabolitefromPenicilliumpaxilli:R.J.Cole,etal.;Can.J.Microbiol.20,1159(1974)
- Tremorgenicindolealkaloidspotentlyinhibitsmoothmusclehigh-conductancecalcium-activatedpotassiumchannels:H.G.Knaus,etal.;Biochemistry33,5819(1994)
- Themycotoxinpaxillineinhibitsthecerebellarinositol1,4,5-trisphosphatereceptor:C.L.Longland,etal.;Eur.J.Pharmacol.408,219(2000)
- Themechanismofinhibitionofthesarco/endoplasmicreticulumCa2+ATPasebypaxilline:J.G.Bilmen,etal.;Arch.Biochem.Biophys.406,55(2002)
- Anaturalproductligandoftheoxysterolreceptor,liverXreceptor:K.S.Bramlett,etal.;J.Pharmacol.Exp.Ther.307,291(2003)
- AnticonvulsanteffectsoftheBK-channelantagonistpaxilline:J.J.Sheehan,etal.;Epilepsia50,711(2009)
- PaxillineenhancesTRAIL-mediatedapoptosisofgliomacellsviamodulationofc-FLIP,survivinandDR5:Y.J.Kang,etal.;Exp.Mol.Med.43,24(2011)
- Glutamate-inducedcelldeathinHT22mousehippocampalcellsisattenuatedbypaxilline,aBKchannelinhibitor:B.Kulawiak&A.Szewczyk;Mitochondrion12,169(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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