Adipogen/Parthenolide/AG-CN2-0455-M010/10 mg
商品编号：
AG-CN2-0455-M010
品牌：
Adipogen Inc
市场价：
¥560.00
美元价：
336.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formula | C15H20O3 |
| MW | 248.3 |
| MerckIndex | 14:7048 |
| CAS | 20554-84-1 |
| RTECS | LY4220000 |
| Source/HostChemicals | IsolatedfromMagnoliagrandiflora. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetolightgreensolid. |
| Solubility | SolubleinDMSO,ethanolordichloromethane.Insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | KTEXNACQROZXEV-PVLRGYAZSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anticancerandantiangiogeniccompound.Inducesapoptosis,cellcyclearrestandautophagyinvariouscancercelllines.
- AtlowconcentrationsactsasantioxidantreducingoxidativestressgeneratedthroughtheTCRsignalingpathway.AthighconcentrationinducesO2-andcausesoxidative-stress-mediatedapoptosis.
- Potentanti-inflammatoryandanti-atheroscleroticagent.
- NF-κBinhibitorbydirectlytargetingIκBkinase.
- InhibitsSTAT-mediatedanti-apoptoticgenetranscription.
- NLRP3inflammasomeinhibitor.InhibitsATPaseactivityofNLRP3andproteaseactivityofcaspase1.
- DirectlybindsthepatternrecognitionreceptorNOD2.
- SpecificallyinhibitsHDAC1withoutaffectingotherclassI/IIHDACs.
- DNAmethyltransferase1(DNMT1)inhibitor.
- InducesubiquitinationofMDM2resultingintheactivationofp53andotherMDM2-regulatedtumorsuppressorproteins.
- VEGFinhibitor.ReducestheexpressionofVEGFanditsreceptorsVEGRF1and2.
- Inhibitstubulincarboxypeptidase(TCP)activity.
- Microtubule-interferingcompound,inhibitingcellmigrationandtubuleformation.
- Anti-leishmanialandanti-trypanosomalagent.
- PartialTRPA1agoNIST.
ProductReferences
- TumorinhibitoryagentfromMagnoliagrandiflora(Magnoliaceae).I.Parthenolide:R.M.Wiedhopf,etal.;J.Pharm.Sci.62,345(1973)
- Theanti-inflammatorynaturalproductparthenolidefromthemedicinalherbFeverfewdirectlybindstoandinhibitsIkappaBkinase:B.H.Kwok,etal.;Chem.Biol.8,759(2001)
- Cellcycleeffectsandcaspase-dependentandindependentdeathofHL-60andJurkatcellstreatedwiththeinhibitorofNF-kappaBparthenolide:P.Pozarowski,etal.;CellCycle2,377(2003)
- Antileishmanialactivityofparthenolide,asesquiterpenelactoneisolatedfromTanacetumparthenium:T.S.Tiuman,etal.;Antimicrob.AgentsChemother.49,176(2005)
- Dualroleoftheanti-inflammatorysesquiterpenelactone:regulationoflifeanddeathbyparthenolide:M.Li-Weber,etal.;CellDeathDiffer.12,408(2005)
- Parthenolideinhibitstubulincarboxypeptidaseactivity:X.Fonrose,etal.;CancerRes.67,3371(2007)
- Parthenolidespecificallydepleteshistonedeacetylase1proteinandinducescelldeaththroughataxiatelangiectasiamutated:Y.N.Gopal,etal.;Chem.Biol.14,813(2007)
- Trypanosomacruzi:antiprotozoalactivityofparthenolideobtainedfromTanacetumparthenium(L.)SchultzBip.(Asteraceae,Compositae)againstepimastigoteandamastigoteforms:E.Izumi,etal.;Exp.Parasitol.118,324(2008)
- ModulationofDNAmethylationbyasesquiterpenelactoneparthenolide:Z.Liu,etal.;J.Pharmacol.Exp.Ther.329,505(2009)
- ParthenolidepromotestheubiquitinationofMDM2andactivatesp53cellularfunctions:Y.N.Gopal,etal.;Mol.CancerTher.8,552(2009)
- Anti-inflammatorycompoundsparthenolideandBay11-7082aredirectinhibitorsoftheinflammasome:C.Juliana,etal.;J.Biol.Chem.285,9792(2010)
- Inhibitionofpatternrecognitionreceptor-mediatedinflammationbybioactivephytochemicals:L.Zhao,etal.;Nutr.Rev.69,310(2011)(Review)
- Parthenolide,asesquiterpenelactone,expressesmultipleanti-cancerandanti-inflammatoryactivities:V.B.Mathema,etal.;Inflammation35,560(2012)(Review)
- ParthenolideinhibitsnociceptionandneurogenicvasodilatationinthetrigeminovascularsystembytargetingtheTRPA1channel:S.Materazzi,etal.;Pain154,2750(2013)
- ParthenolideexertsinhibitoryeffectsonangiogenesisthroughthedownregulationofVEGF/VEGFRsincolorectalcancer:S.L.Kim,etal.;Int.J.Mol.Med.33,1261(2014)
- Parthenolide-inducedapoptosis,autophagyandsuppressionofproliferationinHepG2cells:J.Sun,etal.;AsianPac.J.CancerPrev.15,4897(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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