Adipogen/PARG Inhibitor PDD00017273/AG-CR1-3646-M001/1 mg
商品编号：
AG-CR1-3646-M001
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PARGInhibitorCompound4;1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methylthiazol-5-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide |
| ProductType | Chemical |
| Properties | |
| Formula | C23H26N6O4S2 |
| MW | 514.6 |
| CAS | 1945950-21-9 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,methanoloracetonitrile. |
| InChiKey | IFWUBRBMMNTBRZ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Humanpoly(ADP-ribose)glycohydrolase(PARG)inhibitorforinvitrostudies.
- InhibitshumanrecombinantPARGenzymes(IC50=26nM)andPARGincellassays(IC50=37nM).InactiveagainstrelatedglycohydrolasesARH3andPARP1s(IC50>30µM).Showednocytotoxicity(IC50>30µM).
- Poly(ADPribose)glycohydrolase(PARG)isacriticalcomponentintherepairofsinglestrandDNAbreaksandthereforeatargetincancercells.PARGcounteractsthefunctionoftheARTDfamilyofpoly(ADPribose)polymerases(knownasPARPs)byefficientlycatalysingthehydrolysisofO-glycosidiclinkagesofADP-ribosepolymer,therebyreversingtheeffectsofPARPs.
ProductReferences
- First-in-classchemicalprobesagainstpoly(ADP-ribose)glycohydrolase(PARG)inhibitDNArepairwithdifferentialpharmacologytoOlaparib:D.I.James,etal.;ACSChem.Biol.11,3179(2016)
- SpecifickillingofDNAdamage-responsedeficientcellswithinhibitorsofpoly(ADP-ribose)glycohydrolase:P.Gravells,etal.;DNARepair52,81(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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