Adipogen/Pam3Cys-Ser-(Lys)4 . 3HCl/AG-CP3-0003-M002/2 mg
商品编号：
AG-CP3-0003-M002
品牌：
Adipogen Inc
市场价：
¥7800.00
美元价：
4680.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Pam3CSK4;Pam3Cys-SKKKK;(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH |
| ProductType | Chemical |
| Properties | |
| Formula | C81H156N10O13S.3HCl |
| MW | 1510.3.109.4 |
| CAS | 112208-04-5 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | AbsenceofdetectableproteinorDNAcontaminantswithagoNISTicTLRactivity. |
| Appearance | Colorlesspowder. |
| Solubility | Solubleinwater,salineoraqueousbuffersatpH<7.5.> |
| Reconstitution | Reconstitutein2mlendotoxin-freewatertogeta1mg/mlstocksolution.Useahomogeniserorsonicatortoprepareahomogenoussolution. |
| Formulation | Lyophilized. |
| Concentration | 1mg/mlafterreconstitution. |
| InChiKey | ZRKOETJPZDQIFB-OQOFFOABSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SelectiveagonistofTLR1/TLR2complex.
- Cellpermeable,watersolublesyntheticcationiclipohexapeptideanalogoftheimmunologicallyactiveN-terminalportionofbacteriallipoproteinthatpotentlyactivatesmonocytesandmacrophages.
- Potentandeffectiveimmuneadjuvant.Exertsstronglocalresponse,enhancesIgG2aandIgG1titersandupregulatesproinflammatoryandTh1cytokinegenes.
- PotentactivatoroftheproinflammatorytranscriptionfactorNF-κB.
ProductReferences
- Lipopeptidederivativesofbacteriallipoproteinconstitutepotentimmuneadjuvantscombinedwithorcovalentlycoupledtoantigenorhapten:A.Reitermann,etal.;Biol.Chem.HoppeSeyler370,343(1989)
- Inductionoftumorcytotoxicityinmurinebonemarrow-derivedmacrophagesbytwosyntheticlipopeptideanalogues:P.Hoffmann,etal.;Biol.Chem.HoppeSeyler370,575(1989)
- ActivationofsuperoxideformationandlysozymereleaseinhumanneutrophilsbythesyntheticlipopeptidePam3Cys-Ser-(Lys)4.Involvementofguanine-nucleotide-bindingproteinsandsynergismwithchemotacticpeptides:R.Seifert,etal.;Biochem.J.267,795(1990)
- Synthesisofnovelimmunologicallyactivetripalmitoyl-S-glycerylcysteinyllipopeptidesasusefulintermediatesforimmunogenpreparations:J.Metzger,etal.;Int.J.Pept.ProteinRes.37,46(1991)
- Theinfluenceofvariousadjuvantsonantibodysynthesisfollowingimmunizationwithanhapten:J.Kellner,etal.;Biol.Chem.HoppeSeyler373,51(1992)
- Lipopeptidesareeffectivestimulatorsoftyrosinephosphorylationinhumanmyeloidcells:S.Offermanns,etal.;Biochem.J.282,551(1992)
- ComparisonofadjuvantformulationsforcytotoxicTcellinductionusingsyntheticpeptides:C.E.Hioe,etal.;Vaccine14,412(1996)
- CellActivationandApoptosisbyBacterialLipoproteinsThroughToll-likeReceptor-2:A.O.Aliprantis,etal.;Science285,736(1999)
- Adjuvanteffectsofvariouslipopeptidesandinterferon-gammaonthehumoralimmuneresponseofchickens:M.H.Erhard,etal.;Poult.Sci.79,1264(2000)
- ImmunostimulationbythesyntheticlipopeptideP3CSK4:TLR4-independentactivationoftheERK1/2signaltransductionpathwayinmacrophages:M.R.Muller,etal.;Immunology103,49(2001)
- LipopeptidestructuredeterminesTLR2dependentcellactivationlevel:U.Buwitt-Beckmann,etal.;FEBSJ.272,6354(2005)
- TLR1-andTLR6-independentrecognitionofbacteriallipopeptides:U.Buwitt-Beckmann,etal.;J.Biol.Chem.281,9049(2006)
- HumanLangerhanscellsselectivelyactivatedviaToll-likereceptor2agonistsacquiremigratoryandCD4+Tcellstimulatorycapacity:M.Peiser,etal.;J.Leukoc.Biol.83,1118(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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