Adipogen/Paclitaxel/AG-CN2-0045-M025/25 mg
商品编号：
AG-CN2-0045-M025
品牌：
Adipogen Inc
市场价：
¥1840.00
美元价：
1104.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Taxol;BMS181339-01;NSC125973 |
| ProductType | Chemical |
| Properties | |
| Formula | C47H51NO14 |
| MW | 853.9 |
| MerckIndex | 14:6982 |
| CAS | 33069-62-4 |
| Source/HostChemicals | Isolatedfromthebarkofthepacificyewtree(Taxusbrevifolia). |
| PurityChemicals | ≥99%(HPLC) |
| Appearance | Whitepowder. |
| Solubility | SolubleinDMSO,ethanoloracetonitrile. |
| Identity | DeterminedbyMS&1H-NMR. |
| InChiKey | RCINICONZNJXQF-MZXODVADSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anticancercompound[1,11,14].
- ChemotherapeuticusedinpatientswithcancerandadvancedformsofKaposi"ssarcoma[11,12].
- Microtubuleassemblystabilizer.ReversIBLybindstopolymerizedtubulin[2,3,6,13,14].
- Anti-mitotic.Mitoticspindleassembly,chromosomesegregationandcelldivisioninhibitor.InducescellcyclearrestattheG2/Mphase[4,5,10,13].
- Apoptosisinducerthroughaberrantactivationofcyclin-dependentkinases(CKDs)andthec-JunN-terminalkinase/stressactivatedproteinkinase(JNK/SAPK)[7-9,10].
- Immunosuppressor.Immunostimulant[15].
- Antiproliferativeagentforthepreventionofrestenosis[16].
- TRAILsensitizer[17]
ProductReferences
- Cytotoxicstudiesofpaclitaxel(Taxol®)inhumantumourcelllines:J.E.LieBMAnn,etal.;Br.J.Cancer68,1104(1993)
- Taxol(paclitaxel):mechanismsofaction:S.B.Horwitz;Ann.Oncol.5,S3(1994)(Review)
- Taxol(paclitaxel):anovelanti-microtubuleagentwithremarkableanti-neoplasticactivity:R.Foa,etal.;Int.J.Clin.Lab.Res.24,6(1994)(Review)
- Taxol-inducedmitoticblocktriggersrapidonsetofap53-independentapoptoticpathway:C.M.Woods,etal.;Mol.Med.1,506(1995)
- Tubulinasatargetforanticancerdrugs:agentswhichinteractwiththemitoticspindle:A.Jordan,etal.;Med.Res.Rev.18,259(1998)
- HowTaxolstabilisesmicrotubulestructure:L.A.Amos&J.Löwe;Chem.Biol.6,R65(1999)(Review)
- MechanismsofTaxol-inducedcelldeathareconcentrationdependent:K.Torres&S.B.Horwitz;CancerRes.58,3620(1998)
- Moleculareffectsofpaclitaxel:mythsandreality(acriticalreview):M.V.Blagosklonny&T.Fojo;Int.J.Cancer83,151(1999)
- Microtubuledysfunctioninducedbypaclitaxelinitiatesapoptosisthroughbothc-JunN-terminalkinase(JNK)dependentand-independentpathwaysinovariancancercells:T.H.Wang,etal.;J.Biol.Chem.274,8208(1999)
- Paclitaxel-inducedcelldeath:wherethecellcycleandapoptosiscometogether:T.H.Wang,etal.;Cancer88,2619(2000)
- Paclitaxelincancertherapy:T.M.Mekhail&M.Markman;ExpertOpin.Pharmacother.3,755(2002)
- Overcomingmultidrugresistanceintaxanechemotherapy:R.Geney,etal.;Clin.Chem.Lab.Med.40,918(2002)
- Taxanes:microtubuleandcentrosometargets,andcellcycledependentmechanismsofaction:M.Abal,etal.;Curr.CancerDrugTargets300,193(2003)
- Microtubule-stabilizingnaturalproductsaspromisingcancertherapeutics:B.M.GallagherJr.;Curr.Med.Chem.14,2959(2007)
- Paclitaxelandimmunesystem:A.Javeed,etal.;Eur.J.Pharm.Sci.38,283(2009)(Review)
- Anti-proliferativecompoundsforthepreventionofrestenosis:M.C.Lavigne;Curr.Pharm.Des.16,3989(2010)
- NovelHTSstrategyidentifiesTRAIL-sensitizingcompoundsactingspecificallythroughtheCaspase-8apoptoticaxis:D.Finlay,etal.;PLoSOne5,e13375(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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