Adipogen/Oxaliplatin/AG-CR1-3592-M100/100 mg
商品编号：
AG-CR1-3592-M100
品牌：
Adipogen Inc
市场价：
¥2300.00
美元价：
1380.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 1-OHP;ACT078;RP54780;NSC266046;Diaminocyclohexaneoxalatoplatinum |
| ProductType | Chemical |
| Properties | |
| Formula | C8H14N2O4Pt |
| MW | 397.3 |
| MerckIndex | 14:6912 |
| CAS | 61825-94-3 |
| RTECS | TP2275850 |
| PurityChemicals | ≥98%(1H-NMR) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSOorwater.Slightlysolubleinmethanol.Insolubleinethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | ZROHGHOFXNOHSO-USPAICOZSA-L |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentplatinum-basedantineoplasticagentwithwidespectrumanticanceractivity[2,7-9].
- Anticancercompound.Formsinter-andintrastrandDNAadducts/crosslinks,consequentlyblockingDNAreplicationandtranscriptionandinducingcelldeath[1,4,7,10,13].
- Showsantitumoractivityincisplatinresistantcelllines[3,8].
- Showsbetterbiochemical,pharmacologicalandcytotoxicpropertiesthancisplatin(Prod.No.AG-CR1-3590)andcarboplatin(Prod.No.AG-CR1-3591)[5,7,8].
- Apoptosisinducer[10,11].
- Targetsotherproteinsandenzymes[6].
- Anticanceractivityandantitumorspecificitydependsonselectiveuptakethroughhumanorganiccationtransporters1(OCT1)andOCT2[12].
- Neurotoxicprofiledependsonorganiccationtransporter2(OCT2)uptake[14].
ProductReferences
- Cytotoxicity,cellularaccumulationandDNAbindingofoxaliplatinisomers:L.Pendyala,etal.;CancerLett.97,177(1995)
- Oxaliplatin:mechanismofactionandantineoplasticactivity:E.Raymond,etal.;Semin.Oncol.25,4(1998)(Review)
- InductionofJNKandc-Ablsignallingbycisplatinandoxaliplatininmismatchrepair-proficientand-deficientcells:ANehme,etal.;Br.J.Cancer79,1104(1999)
- Oxaliplatin-induceddamageofcellularDNA:J.M.Woynarowski,etal.;Mol.Pharmacol.58,920(2000)
- Whatisthe"best"platinum:cisplatin,carboplatin,oroxaliplatin?J.Lokich;CancerInvest.19,756(2001)
- Biomoleculartargetsforplatinumantitumordrugs:R.N.Bose;MiniRev.Med.Chem.2,103(2002)
- Cellularandmolecularaspectsofdrugsofthefuture:oxaliplatin:A.M.DiFrancesco,etal.;Cell.Mol.LifeSci.59,1914(2002)(Review)
- Cellularandmolecularpharmacologyofoxaliplatin:E.Raymond,etal.;Mol.CancerTher.1,227(2002)
- Newcluesforplatinumantitumorchemistry:KineticallycontrolledmetalbindingtoDNA:J.Reedijk;PNAS100,3611(2003)
- DNAstrandbreaksandapoptosisinducedbyoxaliplatinincancercells:S.Faivre,etal.;Biochem.Pharmacol.66,225(2003)
- ApoptosisinducedbyoxaliplatininhumancoloncancerHCT15cellline:P.Marchetti,etal.;AnticancerRes.24,219(2004)
- Organiccationtransportersaredeterminantsofoxaliplatincytotoxicity:S.Zhang,;etal.;CancerRes.66,8847(2006)
- Inhibitionoftranscriptionbyplatinumantitumorcompounds:R.C.Todd&S.J.Lippard;Metallomics1,280(2009)(Review)
- Oxaliplatin-inducedneurotoxicityisdependentontheorganiccationtransporterOCT2:J.A.Sprowl,etal.;PNAS110,11199(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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