![Adipogen/Oprozomib [ONX 0912]/AG-CR1-3672-M025/25 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-3672.png)
Adipogen/Oprozomib [ONX 0912]/AG-CR1-3672-M025/25 mg
商品编号：
AG-CR1-3672-M025
品牌：
Adipogen Inc
市场价：
¥6600.00
美元价：
3960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | O-Methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-serinamide;PR-047 |
| ProductType | Chemical |
| Properties | |
| Formula | C25H32N4O7S |
| MW | 532.6 |
| CAS | 935888-69-0 |
| PurityChemicals | ≥98% |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO(20mg/ml)orDMF(10mg/ml).Sparinglysolubleinethanol(1mg/ml).Poorlysolubleinaqueousbuffers. |
| OtherProductData | Note:Warmingandsonicationmayberequiredwhendissolvingthecompoundinthesolventofchoice.Stocksolutionsarestableforatleast1monthwhenstoredat-20°C. |
| InChiKey | SWZXEVABPLUDIO-WSZYKNRRSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentorallybioavailableirreversIBLeproteasomeinhibitor.AnalogofCarfilzomib(Prod.No.AG-CR1-3669).
- Targetsthechymotrypsin-likeβ5subunitoftheconstitutive20Sproteasome(IC50=36nM)andtheβ5isubunit[LMP7]ofthe20Simmunoproteasome(IC50=82nM).
- Anticancercompoundeffectiveincell-basedassays,inxenograftsandagainstmultiplemyelomainvivo.
- Invitro,inducescellcyclearrestandapoptosisinhumancancercelllinesincludingmultiplemyeloma,aswellasinbortezomibresistantmultiplemyelomacells.
- Showntohaveanti-angiogenicactivity.
- Haspotentialapplicationsincertaintypesofcanceraswellasotherdiseasesthatrequireproteasomeactivity.
ProductReferences
- Designandsynthesisofanorallybioavailableandselectivepeptideepoxyketoneproteasomeinhibitor(PR-047):H.J.Zhou,etal.;J.Med.Chem.52,3028(2009)
- AnovelorallyactiveproteasomeinhibitorONX0912triggersinvitroandinvivocytotoxicityinmultiplemyeloma:D.Chauhan,etal.;Blood116,4906(2010)
- Theepoxyketone-basedproteasomeinhibitorscarfilzomibandorallybioavailableoprozomibhaveanti-resorptiveandbone-anabolicactivityinadditiontoanti-myelomaeffects:M.A.Hurchla,etal.;Leukemia27,430(2013)
- CarfilzomibandONX0912inhibitcellsurvivalandtumorgrowthofheadandneckcancerandtheiractivitiesareenhancedbysuppressionofMcl-1orautophagy:Y.Zang,etal.;Clin.CancerRes.18,5639(2012)
- ThenextgenerationproteasomeinhibitorscarfilzomibandoprozomibactivateprosurvivalautophagyviainductionoftheunfoldedproteinresponseandATF4:Y.Zang,etal.;Autophagy8,1873(2012)
- Effectofnovelproteasomeandimmunoproteasomeinhibitorsondendriticcellmaturation,function,andexpressionofIκBandNFκB:A.S.Al-Homsi,etal.;Transpl.Immunol.29,1(2013)
- Overviewofproteasomeinhibitor-basedanti-cancertherapies:Perspectiveonbortezomibandsecondgenerationproteasomeinhibitorsversusfuturegenerationinhibitorsofubiquitin-proteasomesystem:Q.P.Dou&J.A.Zonder;Curr.CancerDrugTargets14,517(2014)
- Proteasomeinhibitors-molecularbasisandcurrentperspectivesinmultiplemyeloma:L.Kubiczkova,etal.;J.Cell.Mol.Med.18,947(2014)
- Next-generationproteasomeinhibitoroprozomibsynergizeswithmodulatorsoftheunfoldedproteinresponsetosuppresshepatocellularcarcinoma:Y.P.Vandewynckel,etal.;Oncotarget7,34988(2016)
- SecondGenerationProteasomeInhibitorsinMultipleMyeloma:A.Gozzetti,etal.;AnticancerAgentsMed.Chem.17,920(2017)
- Anti-angiogenicandanti-multiplemyelomaeffectsofoprozomib(OPZ)aloneandincombinationwithpomalidomide(Pom)and/ordexamethasone(Dex):E.Sanchez,etal.;Leuk.Res.57,45(2017)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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