Adipogen/Ophiobolin A/AG-CN2-0431-M001/1 mg
商品编号：
AG-CN2-0431-M001
品牌：
Adipogen Inc
市场价：
¥5000.00
美元价：
3000.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CochliobolinA;Ophiobalin;NSC114340 |
| ProductType | Chemical |
| Properties | |
| Formula | C25H36O4 |
| MW | 400.6 |
| CAS | 4611-05-6 |
| RTECS | RL1576000 |
| Source/HostChemicals | IsolatedfromBipolarisleersia. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | Solubleinethanol,methanol,DMSOordimethylformamide.Poorlysolubleinwater. |
| InChiKey | MWYYLZRWWNBROW-BDZRSQQBSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepunderinertgas. Protectfromlight. Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,irreversIBLecalmodulinantagoNIST.Actsbycovalentlybindingtoalysine-richinhibitorysite.InhibitsbyblockingtheactivationoftheCa2+/calmodulin-dependentphosphodiesterase[1-3,5,6,9].
- Herbicidalmycotoxin[7].
- Phytotoxic,antifungal,antibacterialandnematocidalcompound[4,6,10].
- Anticancercompound.Showntoinduceparaptosis-likecelldeath[11,12].
- ShowntoinhibitP-glycoprotein-mediatedtransport[8].
- Disruptorofintracellularsulfhydrylproteostasis,leADIngtoERstressanddilation.
ProductReferences
- OphiobolinA.Anaturalproductinhibitorofcalmodulin:P.C.Leung,etal.;J.Biol.Chem.259,2742(1984)
- RoleofCalmodulinInhibitionintheModeofActionofOphiobolinA:P.C.Leung,etal.;PlantPhysiol.77,303(1985)
- CharacterizationoftheinteractionofophiobolinAandcalmodulin:P.C.Leung,etal.;Int.J.Biochem.20,1351(1988)
- MicrobialmetabolitesofophiobolinAandantimicrobialevaluationofophiobolins:E.Li,etal.;J.Nat.Prod.58,74(1995)
- IdentificationofthebindingandinhibitionsitesinthecalmodulinmoleculeforophiobolinAbysite-directedmutagenesis:T.KongAu&P.ChowLeung;PlantPhysiol.118,965(1998)
- TheBIOLOGyofophiobolins:T.K.Au,etal.;LifeSci.67,733(2000)(Review)
- HerbicidalpotentialofophiobolinsproducedbyDrechsleragigantea:A.Evidente,etal.;J.Agric.FoodChem.54,1779(2006)
- InhibitionofP-glycoprotein-mediatedtransportbyterpenoidscontainedinherbalmedicinesandnaturalproducts:N.Yoshida,etal.;FoodChem.Toxicol.44,2033(2006)
- Calciumdepletionandcalmodulininhibitionaffecttheimportofnuclear-encodedproteinsintoplantmitochondria:S.Kuhn,etal.;PlantJ.58,694(2009)
- Effectofthesesterterpene-typemetabolites,ophiobolinsAandB,onzygomycetesfungi:K.Krizsan,etal.;FEMSMicrobiol.Lett.313,135(2010)
- OphiobolinAinducesparaptosis-likecelldeathinhumanglioblastomacellsbydecreasingBKCachannelactivity:M.Bury,etal.;CellDeathDis.4,e561(2013)
- OphiobolinA,asesterterpenoidfungalphytotoxin,displayshigherinvitrogrowth-inhibitoryeffectsinmammalianthaninplantcellsanddisplaysinvivoantitumoractivity:M.Bury,etal.;Int.J.Oncol.43,575(2013)
- OphiobolinAkillshumanglioblastomacellsbyinducingendoplasmicreticulumstressviadisruptionofthiolproteostasis:I.Y.Kim,etal.;Oncotarget8,106740(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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