Adipogen/ONX 0914/AG-CR1-3674-M001/1 mg
商品编号：
AG-CR1-3674-M001
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide;PR-957 |
| ProductType | Chemical |
| Properties | |
| Formula | C31H40N4O7 |
| MW | 580.7 |
| CAS | 960374-59-8 |
| PurityChemicals | ≥98% |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO(30mg/ml),ethanol(20mg/ml)orDMF.Poorlysolubleinaqueoussolutions. |
| OtherProductData | Note:Warmingandsonicationmayberequiredwhendissolvingthecompoundinthesolventofchoice. |
| InChiKey | WQAVPPWWLLVGFK-VTNASVEKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentandselective20Simmunoproteasomeinhibitor.
- Targetstheβ5isubunit[LMP7]ofthe20Simmunoproteasome(IC50=73nM)andwithminimalcross-reactivitytothechymotrypsin-likeβ5subunitoftheconstitutive20Sproteasome(IC50=1.04µM).
- Potentanti-inflammatoryandanticanceragent.Inhibitsproductionofpro-inflammatorycytokinesandcaninduceapoptosisinvitro.
- InhibitspresentationofLMP7-specific,MHC-I-restrictedantigensinvitroandinvivo,whichconsequentlyblocksproductionofinterleukin-23(IL-23)byactivatedmonocytesandIFN-γandIL-2byTcells.CanalsoinhibitIL-17-producingTcellsunderTH17-polarizingconditionsinvitroandreduceTH1andTH17celldifferentiationinvivo.
- Showntoattenuatediseaseprogressioninseveralexperimentalmodelsofautoimmunedisorders,suchasrheumatoidarthritis,inflammatoryboweldiseaseandlupus,aswellasinsomehematologicmalignanciesandothercancertypes.
ProductReferences
- AselectiveinhibitoroftheimmunoproteasomesubunitLMP7blockscytokineproductionandattenuatesprogressionofexperimentalarthritis:T.Muchamuel,etal.;Nat.Med.15,781(2009)
- Preventionofexperimentalcolitisbyaselectiveinhibitoroftheimmunoproteasome:M.Basler,etal.;J.Immunol.185,634(2010)
- Immunoproteasome-specificinhibitorsandtheirapplication:M.Basler&M.Groettrup;MethodsMol.Biol.832,391(2012)
- ProphylacticandtherapeuticefficaciesofaselectiveinhibitoroftheimmunoproteasomeforHashimoto"sthyroiditis,butnotforGraves"hyperthyroidism,inmice:Y.Nagayama,etal.;Clin.Exp.Immunol.168,268(2012)
- ImmunoproteasomesubunitLMP7deficiencyandinhibitionsuppressesTh1andTh17butenhancesregulatoryTcelldifferentiation:K.W.Kalim,etal.;J.Immunol.189,4182(2012)
- Inhibitionoftheimmunoproteasomeamelioratesexperimentalautoimmuneencephalomyelitis:M.Basler,etal.;EMBOMol.Med.6,226(2014)
- Interferon-γ-inducedupregulationofimmunoproteasomesubunitassemblyovercomesbortezomibresistanceinhumanhematologicalcelllines:D.Niewerth,etal.;J.Hematol.Oncol.7,7(2014)
- Bortezomib-resistantmutantproteasomes:structuralandbiochemicalevaluationwithcarfilzomibandONX0914:E.M.Huber,etal.;Structure23,407(2015)
- InhibitionoftheImmunoproteasomeSubunitLMP7withONX0914AmelioratesGraft-versus-HostDiseaseinanMHC-MatchedMinorHistocompatibilityAntigen-DisparateMurineModel:J.Zilberberg,etal.;Biol.BloodMarrowTransplant21,1555(2015)
- PR-957,aselectiveinhibitorofimmunoproteasomesubunitlow-MWpolypeptide7,attenuatesexperimentalautoimmuneneuritisbysuppressingTh17-celldifferentiationandregulatingcytokineproduction:H.Liu,etal.;FASEBJ.31,1756(2017)
- InhibitionanddeficiencyoftheimmunoproteasomesubunitLMP7suppressthedevelopmentandprogressionofcolorectalcarcinomainmice:J.Koerner,etal.;Oncotarget(Epubaheadofprint)(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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