Adipogen/Olaparib/SYN-3043-M010/10 mg
商品编号：
SYN-3043-M010
品牌：
Adipogen Inc
市场价：
¥2600.00
美元价：
1560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AZD-2281;KU-59436;4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one |
| ProductType | Chemical |
| Properties | |
| Formula | C24H23FN4O3 |
| MW | 434.2 |
| CAS | 763113-22-0 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:PARP|KinaseGroup:N/A|Substrate:N/A ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | FDLYAMZZIXQODN-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
ThePARPinhibitorOlaparib(AZD2281)isasmallmoleculeinhibitorofthenuclearenzymepoly(ADP-ribose)polymerase(PARP)withpotentialchemosensitizing,rADIosensitizingandantineoplasticactivities.OlaparibselectivelybindstoandinhibitsPARP(IC50of1-5nMincell-freeassays),inhibitingPARP-mediatedrepairofsinglestrandDNAbreaks;PARPinhibitionmayenhancethecytotoxicityofDNA-damagingagentsandmayreversetumorcellchemoresistanceandradioresistance.PARPcatalyzespost-translationalADP-ribosylationofnuclearproteinsandcanbeactivatedbysingle-strandedDNAbreaks.
ProductReferences
- 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one:anovelbioavailableinhibitorofpoly(ADP-ribose)polymerase-1:K.A.Menear,etal.;J.Med.Chem.51,6581(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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