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Adipogen/Okadaic acid . sodium salt (high purity)/AG-CN2-0062-M001/1 mg
Adipogen/Okadaic acid . sodium salt (high purity)/AG-CN2-0062-M001/1 mg
商品编号：
AG-CN2-0062-M001
品牌：
Adipogen Inc
市场价：
¥23000.00
美元价：
13800.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HalochondrineA;CCRIS3329;HSDB7243;9,10-Deepithio-9,10-didehydroacanthifolicin |
| ProductType | Chemical |
| Properties | |
| Formula | C44H67O13.Na |
| MW | 804.0.23.0 |
| CAS | 209266-80-8 |
| Source/HostChemicals | IsolatedfromProrocentrumconcavum.Saltformgeneratedinaqueoussodiumhydroxide-methanolsolution. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,ethanol,methanol,acetone,ethylacetateordistilledwater.Dissolvefirstinorganicsolventbeforedilutinginwater. |
| OtherProductData | Saltformofokadaicacid(Prod.No.AG-CN2-0056)withslightlygreaterstABIlitythanthefreeacidafteritisputintostocksolution(inorganicsolvents). |
| InChiKey | BYHIFOCTDVNQQT-PZRPKHTISA-M |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/Stability | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Non-phorboltypetumorpromoter[1].
- ReversIBLe,potentandselectiveserinethreonineproteinphosphataseinhibitor.PP2A(IC50=0.2-1nM),PP1(IC50=3-15nM),PP2B(IC50=>1µM).DoesnotinhibitPP2C[2,6,7,18].
- Stimulatesintracellularproteinphosphorylation[3].
- Usefultoolforstudyingcellularprocessesthatareregulatedbyphosphorylation.Doesnotaffectactivityofacidphosphatase,alkalinephosphataseandtyrosinephosphatase[4,5].
- Mimicstheeffectsofinsulin[7].ActivatesatypicalproteinkinaseC(ζ/&lamBDa;)in3T3/L1ADIpocytes[14,19].
- Enhancestransmitterreleaseatneuromuscularjunctions[8].
- Apoptosisinhibitor[9,11,12].
- Inducesapoptosisinhumanbreastcarcinomacells(MB-231andMCF-7)andinmyeloidcells[10].
- Neurotoxic[12,16].
- Usedtostudyvariouscellularprocessesincludingcellcycle,apoptosis,nitricoxidemetabolismandcalciumsignaling[13,15,17,18].
- Stimulatescellmotility,lossofstabilizationoffocaladhesionsandaconsequentlossofcytoskeletalorganization[20].
ProductReferences
- Okadaicacid:anadditionalnon-phorbol-12-tetradecanoate-13-acetate-typetumorpromoter:M.Suganuma,etal.;PNAS85,1768(1988)
- Inhibitoryeffectofamarine-spongetoxin,okadaicacid,onproteinphosphatases.Specificityandkinetics:C.Bialojan&A.Takai;Biochem.J.256,283(1988)
- Effectsofthetumourpromoterokadaicacidonintracellularproteinphosphorylationandmetabolism:T.A.Haystead,etal.;Nature337,78(1989)
- Animprovedprocedureforidentifyingandquantitatingproteinphosphatasesinmammaliantissues:P.Cohen,etal.;FEBSLett.250,596(1989)
- Okadaicacid:anewprobeforthestudyofcellularregulation:P.Cohen,etal.;TIPS15,98(1990)(Review)
- Useofokadaicacidtoinhibitproteinphosphatasesinintactcells:D.G.Hardie,etal.;MethodsEnzymol.201,469(1991)
- Effectsof okadaicacid,aninhibitorofproteinphosphatases-1and-2A,onglucosetransportandmetabolisminskeletalmuscle:J.F.Tanti,etal.;J.Biol.Chem.266,2099(1991)
- Proteinphosphataseinhibitorokadaicacidenhancestransmitterreleaseatneuromuscularjunctions:M.Abdul-Ghani,etal.;PNAS88,1803(1991)
- Inhibitionofapoptosisinhumantumourcellsbyokadaicacid:Q.Song,etal.;J.CellPhysiol.153,550(1992)
- Differentialinductionofapoptosisinhumanbreasttumorcellsbyokadaicacidandrelatedinhibitorsofproteinphosphatases1and2A:K.Kiguchi,etal.;CellGrowthDifferentiation5,995(1994)
- Differentialinhibitionandposttranslationalmodificationofproteinphosphatase1and2AinMCF7cellstreatedwithcalyculin-A,okadaicacid,andtautomycin:B.Favre,etal.;J.Biol.Chem.272,13856(1997)
- Okadaicacid-inducedapoptosisinneuronalcells:evidenceforanabortivemitoticattempt:R.Nuydens,etal.;J.NeuRochem. 70, 1124(1998)
- Inhibitorsofproteinphosphatase1and2Adifferentiallyregulatetheexpressionofinduciblenitric-oxidesynthaseinratastrocytesandmacrophages:K.Pahan,etal.; J.Biol.Chem. 273,12219(1998)
- OkadaicacidactivatesatypicalproteinkinaseC(zeta/lambda)inratand3T3/L1adipocytes.AnapparentrequirementforactivationofGlut4translocationandglucosetransport:M.L.Standaert,etal.;J.Biol.Chem.274,14074(1999)
- Uniquefeaturesoftheokadaicacidactivityclassoftumorpromoters:H.Fujiki&M.Suganuma;J.CancerRes.Clin.Oncol.125,150(1999)(Review)
- Neurotoxicandsynapticeffectsof okadaicacid,aninhibitorofproteinphosphatases:R.Tapia,etal.;Neurochem.Res.24,1423(1999) (Review)
- Okadaicacid,usefultoolforstudyingcellularprocesses:J.J.Fernández,etat.;Curr.Med.Chem.9,229(2002) (Review)
- Okadaicacid:thearchetypalserine/threonineproteinphosphataseinhibitor:A.B.Dounay&C.J.Forsyth;Curr.Med.Chem.9,1939(2002)(Review)
- Effectof okadaicacid onglucoseregulation:M.C.Louzao,etat.;MiniRev.Med.Chem.5,207(2005) (Review)
- MarinetoxinsandtheCytoskeleton: okadaicacid anddinophysistoxins:C.Vale&L.M. Botana;FEBSJ.275,6060(2008) (Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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