Adipogen/ODQ/AG-CR1-3500-M010/10 mg
商品编号：
AG-CR1-3500-M010
品牌：
Adipogen Inc
市场价：
¥1000.00
美元价：
600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 1H-[1,2,4]OxADIazole[4,3-a]quinoxalin-1-one |
| ProductType | Chemical |
| Properties | |
| Formula | C9H5N3O2 |
| MW | 187.2 |
| CAS | 41443-28-1 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetopaleyellowsolid. |
| Solubility | SolubleinDMSO(atleast5mg/ml),ethylacetateor100%ethanol(1.2mg/ml);insolubleinwater. |
| OtherProductData | Storeinthedark.Solutionsmaydecomposeslowly. |
| InChiKey | LZMHWZHOZLVYDL-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentandhighlyselective,irreversIBLeinhibitorofsolubleguanylylcyclase(sGC).Thebindingiscompetitivewithnitricoxide(NO)[1-5].
- Tooltoelucidatethenitricoxide(NO)-cGMPpathway[1-5].
- Apoptosisinhibitor[6]
- InhibitsgrowthandmigrationofprostatecancercellsindependentofitseffectsonGMPlevels[6].
ProductReferences
- Nitricoxide-dependentlong-termpotentiationisblockedbyaspecificinhibitorofsolubleguanylylcyclase:C.L.Boulton,etal.;Neuroscience69,699(1995)
- Novelguanylylcyclaseinhibitor,ODQrevealsroleofnitricoxide,butnotofcyclicGMPinendothelin-1secretion:F.Brunner,etal.;FEBSLett.376,262(1995)
- Potentandselectiveinhibitionofnitricoxide-sensitiveguanylylcyclaseby1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one:J.Garthwaite,etal.;Mol.Pharmacol.48,184(1995)
- Characterizationof1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-oneasaheme-siteinhibitorofnitricoxide-sensitiveguanylylcyclase:A.Schrammel,etal.;Mol.Pharmacol.50,1(1996)
- InhibitionofSolubleGuanylateCyclasebyODQ:Y.Zhao,etal.;Biochemistry39,10848(2000)
- cGMP-independentanti-tumouractionsoftheinhibitorofsolubleguanylylcyclase,ODQ,inprostatecancercelllines:G.Haramis,etal.;Br.J.Pharmacol.155,804(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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