Adipogen/OCH/AG-CR1-3593-M001/1 mg
商品编号：
AG-CR1-3593-M001
品牌：
Adipogen Inc
市场价：
¥4800.00
美元价：
2880.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-N-tetracosanoyl-2-amino-1,3,4-nonanetriol) |
| ProductType | Chemical |
| Properties | |
| Formula | C39H77NO9 |
| MW | 704.0 |
| CAS | 383187-82-4 |
| PurityChemicals | ≥95% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,100%ethanol(warm)ormethanol(warm). |
| InChiKey | MPKIDHIOYNMFES-CLTBVUQJSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterstandardreconstitution,preparealiquotsandstoreat-20°C. Aliquotintoglassvials. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Truncatedanalogofα-GalCer.
- iNKTcellglycolipidagoNIST.
- Immunosuppressive.
- Th2polarizing.StimulationofNKTwithOCHresultsinreleaseofprimarilyTh2cytokinecomparedtostimulationwithα-GalCer,whichresultsinreleaseofamixtureofTh1andTh2cytokines.
- Inducesstrongerinterleukin-4(IL-4)secretionandweakerinterferon-γ(IFN-γ)secretionthanα-GalCerbothinvitroandinvivo.
- Inducerofinterleukin-10(IL-10)andsuppressorofdiabetes.
- Showntopreventexperimentalautoimmuneencephalomyelitis(EAE)inmice,ananimalmodelofmultiplesclerosis.
- HasbeneficialeffectsontypeIdiabetesinNODmice.
- Suppressorofcollagen-inducedarthritis.
- Mightbeusefulforimmunotherapyoftransplantrejection.
ProductReferences
- AsyntheticglycolipidpreventsautoimmuneencephalomyelitisbyinducingTH2biasofnaturalkillerTcells:K.Miyamoto,etal.;Nature413,531(2001)
- SyntheticglycolipidOCHpreventsinsulitisanddiabetesinNODmice:M.Mizuno,etal.;J.Autoimmun.23,293(2004)
- TheclinicalimplicationandmolecularmechanismofpreferentialIL-4productionbymodifiedglycolipid-stimulatedNKTcells:S.Oki,etal.;J.Clin.Invest.113,1631(2004)
- Suppressionofcollagen-inducedarthritisbynaturalkillerTcellactivationwithOCH,asphingosine-truncatedanalogofalpha-galactosylceramide:A.Chiba,etal.;ArthritisRheum.50,305(2004)
- Totalsynthesisofanimmunosuppressiveglycolipid,(2S,3S,4R)-1-O-(alpha-d-galactosyl)-2-tetracosanoylamino-1,3,4-nonanetriol:K.Murata,etal.;J.Org.Chem.70,2398(2005)
- SynthesisandevaluationofsphinganineanaloguesofKRN7000andOCH:R.M.Ndonye,etal.;J.Org.Chem.70,10260(2005)
- IFN-γ–mediatednegativefeedbackregulationofNKT-cellfunctionbyCD94/NKG2:T.Ota,etal.;Blood106,184(2005)
- ModulationofCD1d-restrictedNKTcellresponsesbyusingN-acylvariantsofalpha-galactosylceramides:Y.KO,etal.;PNAS102,3383(2005)
- α-Galactosylceramidetherapyforautoimmunediseases:Prospectsandobstacles:L.VanKaer;Nat.Rev.Immunol.5,31(2005)
- GlycolipidsfornaturalkillerTcells:P.B.Savage,etal.;Chem.Soc.Rev.351,771(2006)
- ProlongationofcardiacallograftsurvivalbyrapamycinandtheinvariantnaturalkillerTcellglycolipidagonistOCH:S.M.Haeryfar,etal.;Transplantation86,460(2008)
- Mechanismsforglycolipidantigen-drivencytokinepolarizationbyValpha14iNKTcells:B.A.Sullivan,etal.;J.Immunol.184,141(2010)
- AmolecularbasisfortheexquisiteCD1d-restrictedAntigen-specificityandfunctionalresponsesofNaturalKillerTcells:K.S.Wun,etal.;Immunity34,327(2011)
- Structuralandfunctionalcharacterizationofanovelnon-glycosidiciNKTagonistwithimmunomodulatoryproperties:J.Kerzerho,etal.;J.Immunol.188,2254(2012)
- SynthesisandBIOLOGicalactivityofhydroxylatedanaloguesofKRN7000(α-galactosylceramide):M.Shiozaki,etal.;Carbohydr.Res.370,46(2013)
- iNKTcellcytotoxicresponsescontrolT-lymphomagrowthinvitroandinvivo:H.Bassiri,etal.;CancerImmunol.Res.2,59(2014)
- ImpactofTh1/Th2cytokinepolarityinducedbyinvariantNKTcellsontheincidenceofpregnancylossinmice:M.Hoya,etal.;Am.J.Reprod.Immunol.aheadofprint(2018)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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