Adipogen/NVP-BEZ235/AG-CR1-3633-M005/5 mg
商品编号：
AG-CR1-3633-M005
品牌：
Adipogen Inc
市场价：
¥500.00
美元价：
300.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Dactolisib;BEZ235;4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile |
| ProductType | Chemical |
| Properties | |
| Formula | C30H23N5O |
| MW | 469.5 |
| CAS | 915019-65-7 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleindimethylformamide(~10mg/ml).SligthlysolubleinDMSOorchloroform(~1mg/ml).Warmingandsonicationmightbenecessary.Insolubleinwater. |
| InChiKey | JOGKUKXHTYWRGZ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfrommoistureandoxygen. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentdualATP-competitivepanclassIPI3KandmTORinhibitor(p110α/γ/δ/βandmTOR(p70S6K)withIC50of4nM,5nM,7nM,75nMand6nM,respectively),subsequentlyinducingG1phasearrestinBIOLOGicalcellgrowthandviabilityassays.
- Anticancercompound.Antiproliferativeagainstseveralanimaltumorcelllines,specificallyblockingthedysfunctionalactivationofthePI3Kpathway,
- Enhancestheefficacyofotheranticanceragentswhenusedininvivocombinationstudies.
- StronglyinhibitsVEGF-inducedcellproliferationandsurvivalinvitroandVEGF-inducedangiogenesisinvivo.
- ShowntobeapotentinhibitorofATM-andDNA-PKCs-mediatedDNAdamageandDNAdouble-strandbreakrepair.
- Showntohaveneuroprotectivepropertiesonamyloid-β1-42inducedneurotoxicityandmemoryimpairment.
- Showsanti-trypanosomalactivityforsomeselectedspecies.
ProductReferences
- IdentificationandcharacterizationofNVP-BEZ235,aneworallyavailabledualphosphatidylinositol3-kinase/mammaliantargetofrapamycininhibitorwithpotentinvivoantitumoractivity:S.M.Maira,etal.;Mol.CancerTher.7,1851(2008)
- Effectsofthedualphosphatidylinositol3-kinase/mammaliantargetofrapamycininhibitorNVP-BEZ235onthetumorvasculature:implicationsforclinicalimaging:C.R.Schnell,etal.;CancerRes.68,6598(2008)
- NVP-BEZ235,adualPI3K/mTORinhibitor,preventsPI3KsignalingandinhibitsthegrowthofcancercellswithactivatingPI3Kmutations:V.Serra,etal.;CancerRes68,8022(2008)
- DiscoveryofnovelanticancertherapeuticstargetingthePI3K/Akt/mTORpathway:S.M.Maria,etal.;FutureMed.Chem.1,137(2009)
- Targetingmelanomawithdualphosphoinositide3-kinase/mammaliantargetofrapamycininhibitors:R.Marone,etal.;Mol.CancerRes.7,601(2009)
- ChiariniF,GrimaldiC,RicciF,etal.Activityofthenoveldualphosphatidylinositol3-kinase/mammaliantargetofrapamycininhibitorNVP-BEZ235againstT-cellacutelymphoblasticleukemia:F.Chiarini,etal.;CancerRes.70,8097(2010)
- NVP-BEZ235,adualpanclassIPI3kinaseandmTORinhibitor,promotesosteogenicdifferentiationinhumanmesenchymalstromalcells:S.K.Martin,etal.;J.BoneMiner.Res.25,2126(2010)
- Recentresultsinproteinkinaseinhibitionfortropicaldiseases:D.P.Rotella,etal.;Bioorg.Med.Chem.Lett.22,6788(2012)
- ThedualPI3K/mTORinhibitorNVP-BEZ235isapotentinhibitorofATM-andDNA-PKCs-mediatedDNAdamageresponses:B.Mukherjee,etal.;Neoplasia14,34(2012)
- InhibitionofautophagyasastrategytoaugmentrADIosensitizationbythedualphosphatidylinositol3-kinase/mammaliantargetofrapamycininhibitorNVP-BEZ235:G.J.Cerniglia,etal.;Mol.Pharmacol.82,1230(2012)
- InhibitionofDNAdouble-strandbreakrepairbythedualPI3K/mTORinhibitorNVP-BEZ235asastrategyforradiosensitizationofglioblastoma:C.R.GildelAlcazar,etal.;Clin.CancerRes.20,1235(2014)
- NeuroprotectiveeffectsoftheanticancerdrugNVP-BEZ235(dactolisib)onamyloid-β1-42inducedneurotoxicityandmemoryimpairment:P.M.Bellozi,etal.;Sci.Rep.6,25226(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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